The Korean Journal of Physiology and Pharmacology

The Korean Society of Pharmacology (대한약리학회)
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Expression Profiles of Immune-related Genes in Fluoxetine-treated Human Mononuclear Cells by cDNA Microarray

  • Lee, Hee-Jae (Kohwong Medical Research Institute, College of Medicine, Kyung Hee University) ;
  • Jin, Sheng-Yu (Kohwong Medical Research Institute, College of Medicine, Kyung Hee University) ;
  • Hong, Mee-Suk (Kohwong Medical Research Institute, College of Medicine, Kyung Hee University) ;
  • Li, Guang-Zhe (Kohwong Medical Research Institute, College of Medicine, Kyung Hee University) ;
  • Kim, Jong-Woo (Kohwong Medical Research Institute, College of Medicine, Kyung Hee University) ;
  • Kim, Beom-Sik (Kohwong Medical Research Institute, College of Medicine, Kyung Hee University) ;
  • Chung, Joo-Ho (Kohwong Medical Research Institute, College of Medicine, Kyung Hee University)
  • Published : 2003.10.21
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Abstract

To investigate the effect of fluoxetine, one of selective serotonin reuptake inhibitors (SSRIs), on the immune system, human peripheral blood mononuclear cells (PBMC) were treated with fluoxetine $(10^{-7}\;M)$ for 24 h, and immune-related genes were analyzed by cDNA microarray. Expression of the immunerelated genes such as CD107b (LAMP-2), CD47 receptor (thrombospondin receptor), CD5 antigen-like (scavenger receptor cysteine rich family), copine III (CPNE3), interleukin (IL)-18 (interferon-gammainducing factor), integrin alpha 4 (CD49d), integrin alpha L subunit (CD11a), IL-3 receptor alpha subunit, L apoferritin, and small inducible cytokine subfamily A (Cys-Cys) member 13 (SCYA13) was induced by fluoxetine. This result suggests that fluoxetine may affect the immune system, and provides fundamental data for the involvement of SSRIs on immunoregulation.

Keywords

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