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Inhibitory effects of ethanol extract of Atractylodis Rhizoma on melanogenesis in B16/F10 melanoma cells

  • Chun, Hyun-Ja (Division of Natural Sciences, Wonkwang University) ;
  • Lee, Jeong-Ho (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Choi, Eun-Young (Department of Skin and Care, Kimcheon Science College) ;
  • Baek, Seung-Hwa (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
  • Published : 2003.05.30

Abstract

The inhibitory effect of Atractylodis Rhizoma alba extract(AM) on melanogenesis was studied by using B16/F10 melanoma in culture. Cells were cultured in the presence of various concentrations of AM for 48 hrs, and the experiment of total melanin content as a final product and activity of tyrosinase, a key enzyme, in melanogenesis. AM significantly inhibited tyrosinase activity, and melanin content in a dose-dependent manner. These results show that Atractylodes macrocephala extract could be developed as skin whitening components of cosmetics.

Keywords

References

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