Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Association between I/D Polymorphism of Human LRPAP1 Gene and Body Mass Index in Korean General Population

  • Kang, Byung-Yong (Research Institute for Life Science, Sahmyook University) ;
  • Bae, Hak-Gyoon (Graduate School of Health Science and Social Welfare, Sahmyook University) ;
  • Jhin, Hae-Kyung (Dept. of Child and Adolescent Psychiatry, Seoul National Hospital) ;
  • Lee, Kyung-Soon (Dept. of Nursing, Sahmyook University) ;
  • Lee, Kang-Oh (Dept. of Life Science, Sahmyook University)
  • Published : 2003.09.01
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Abstract

The aim of this study was to estimate the influence of 37 bp insertion/deletion (I/O) poly-morphism of the low density lipoprotein receptor-related protein-associated protein 1 (LRPAP1) gene on anthropometrical or biochemical parameters in korean general population. To determine the frequency of the genotype, we analyzed 244 samples of Korean origin. The frequency of the I allele was 0.55 in men and 0.56 in women, which were significantly higher than the frequency (0.26) that was reported in Czech population of Caucasian origin. In addition, the I allele of this polymorphism was significantly associated with higher value of body mass index (BMI) in our subjects by ANOVA test (P<0.05), and this association was maintained after controlling for age and gender by ANCOVA test (P<0.05). Thus, our results suggest that the I/O polymorphism of the LRPAP1 gene may be useful as a genetic marker for obesity in Korean general population.

Keywords

References

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