Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Study on the Effects of Fructus Schizandrae on the Cerebral Blood Flow and Blood Pressure

뇌혈유와 혈압에 미치는 오미자의 효능에 대한 연구

  • Whang Il Taek (Department of Pharmacology, College of Oriental Medicine) ;
  • Kim Kyung Soo (Department of Pharmacology, College of Oriental Medicine) ;
  • Park Jin Young (Department of Pharmacology, College of Oriental Medicine) ;
  • Kim Chun Soo (Professional Graduate School of Oriental Medicine. Wonkwang University) ;
  • Song Jung Suk (Professional Graduate School of Oriental Medicine. Wonkwang University) ;
  • Han Jong Hyun (Professional Graduate School of Oriental Medicine. Wonkwang University)
  • 황일택 (원광대학교 한의과대학 약리학교실) ;
  • 김경수 (원광대학교 한의과대학 약리학교실) ;
  • 박진영 (원광대학교 한의과대학 약리학교실) ;
  • 김천수 (한의학전문대학원) ;
  • 송정석 (한의학전문대학원) ;
  • 한종현 (한의학전문대학원)
  • Published : 2003.10.01
Download PDF
⟨ Previous Next ⟩

Abstract

The purpose of this present study is to measure the changes of regional cerebral blood flow(rCBF) and blood pressure(BP) in rats. following the intravenous injection of drug. The measurement was continually monitored by laser-doppler flowmeter (Transonic Instrument, USA) and pressure tranducer(Grass, USA) in anesthetized adult Sprague-Dawley rats about for 2h to 2h and a half through the data acquisition system composed of MacLab and Macintosh computer. The result of this experiment was as following. 1. Fructus Schizandrae increased the changes of rCBF in rats, significantly. 2. The rCBF of Fructus Schizandrae did not change by pretreated propranolol. 3. The rCBF of Fructus Schizandrae did not change by pretreated atropine. 4. The rCBF of Fructus Schizandrae did not change by pretreated I-NNA. 5. The rCBF of Fructus Schizandrae was decreased by pretreated methylene blue. 6. The rCBF of Fructus Schizandrae did not change by pretreated indomethacin. 7. Fructus Schizandrae decreased the changes of blood pressure significantly. 8. The BP of Fructus Schizandrae did not change by pretreated propranolol. 9. The BP of Fructus Schizandrae did not change by pretreated atropine. 10. The BP of Fructus Schizandrae did nol change by pretreated I-NNA. 11. The BP of Fructus Schizandrae was decreased by pretreated methylene blue. 12. The BP of Fructus Schizandrae did not change by pretreated indomethacin. These results indicate that Fructus Schizandrae can increase the rCBF and decrease the BP, that related to guanylyl cyclase activity.

Keywords

References

  1. 中藥藥理學 王筠默
  2. 和漢藥物學 高木敬次朗
  3. 中藥大辭典 김창민(외)
  4. 韓藥의 藥理 김형균(외)
  5. 원색 임상본초학 신민교
  6. 본초학 전국한의과대학(편)
  7. 本草綱目 李時珍
  8. 神農本草經校證 王筠默;王恒芬
  9. 한국식품과학학회지 v.5 五味子의 일반성분, 유기산 및 Anthocyanin 색소에 관하여 김경임;남주형;권태완
  10. 한국식품과학학회지 v.22 구기자(Lycium chinensis Miller), 당귀(Angelica acutiloba Kitag), 五味子(Schizandra Chinensis Baillon), 오갈피(Acarnthopanax ses-siliflorum Seeman) 추출물의 유리당, 유리아미노산, 유기산 및 탄닌의 조성 오상룡;김성수;민병용;정동효
  11. Korean Postharvest Sci. Technol. v.5 Studies on drying and preservation of Omija(Schizandra chinensis) Jung, G.T.;Ju, I.O.;Choi, J.S.
  12. Korean J. Food Sci. Technol. v.5 On the proximate composition, organic acid and anthocyanins of Omija, Schizandra chinensis Baillon Kim, K.I.;Nam, J.H.;Kwon, T.W.
  13. Standard agricultural management textbook v.7 Cultivation of herb Lee, D.W.
  14. Korean J. Dietary Culture v.4 The studies of composition of free sugar, fatty acid and nonvolatilitic organic acid in part of Omija(Schizandra chinensis Baillon) Lee, J.S.;Lee, S.W.
  15. Korean Soc. Agri. Chem. Biotechnol. v.25 Anthocyanins in cultured Omija(Schizandra chinensis Baillon) and its stability Yang, H.C.;Lee, J.M.;Song, K.B.
  16. Planta Med. v.50 Validity of the oriental medicines 60. Liver-protective drugs. ⅡAntihepatotoxic action of lignoids from S. chinensis fruits Hikino, H.;Kios, Y.;Takuchi, H.;Ikeya, Y.
  17. Korean J. Dietary Culture v.5 Effect of water extract in fruits of Omija(Schizandra chinensis Baillon) on alcohol metabolism Lee, J.S.;Lee, S.W.
  18. Planta Med v.68 no.3 Schisandrin B protects against tacrine-and bis(7)-tacrine- induced hepatotoxicity and enhances cognitive function in mice Pan, S.Y.;Han, Y.F.;Carlier, P.R.;Pang, Y.P.;Mak, D.H.;Lam, B.Y.;Ko, K.M.
  19. Planta Med v.66 no.6 Improvement of phase I drug metabolism with Schizandra chinensis against CCl4 hepatotoxicity in a rat model Zhu, M.;Yeung, R.Y.;Lin, K.F.;Li, R.C.
  20. J. Korean Soc. Food Sci. Nutri. v.27 Antimicrobial effect of Schizandra chinensis extract on pathogenic microorganism Lee, S.H.;Lim, Y.S.
  21. Korean J. Applied Microbiol. Biotechnol. v.25 Effect of Omija(Schizandra chinensis) extract on the growth of lactic acid bacteria isolated from Kimchi Lee, S.H.;Lim, Y.S.
  22. Korean J. Applied Microbiol. Biotechnol. v.25 Antimicrobial effects of Schizandra chinensis extract against Listeria monocytogenes Lee, S.H.;Lim, Y.S.
  23. Kor. J. Appl. Microbiol. Biotechnol. v.25 no.5 Antimicrobial Effects of Schizandra Chinensis Extract against Listeria moonocytogenes Lee, Shin-Ho;Lim, Yong-Suuk
  24. 五味子의 藥理作用에 관한 硏究 강덕수
  25. Korean J. Soc. Food Nutr. v.24 no.5 Effect of Schizandra Chinensis Extract in Hyperlipidemic Rats Ock, Eun-Sung
  26. Pharmacological Research v.43 no.1 The ameliorating effect of the water layer of FRUCTUS SCHISANDRAE on cycloheximide-induced amnesia in rats: interaction with drugs acting at neurotransmitter receptors Hsieh, Ming-Tsuen;Wu, Chi-Rei;Wang, Wen-Hsin;Lin, Li-Wei
  27. Korean J. Soc. Food Sci. Nutri. v.16 Effect of Schizandrae Fructus extract on blood constituents ofalloxan induced diabetic rabbits Sheo, H.J.;Lee, M.Y.;Hwang, J.S.
  28. Korean J. Dietary Culture. v.4 no.3 Effects of Water Extract of the Parts of Omiza(Schizandra Chinensis Baillon) on Metabolism in Normal Rats Lee, Joung-Sook;Lee, Sunf-Woo
  29. Korean J. Soc. Food Sci. v.12 no.3 Antioxidant effect of Omija (Schizandra Chinensis Baillon) Extracts Jung, Eun-Hee;Pyo, Young-Hee;Ahn, Myung-soo
  30. 日本生藥學會 第24會年會(東京大會)講演要旨集 五味子의 藥理學的 硏究(第I報), gomosin A 및 schizandrin의 中樞作用 前田信也 等
  31. 日本藥學會 第99年會講演要旨集 五味子의 藥理學的 硏究(第II報), gomosin A 및 schizandrin의 末梢作用 前田信也 等
  32. Arch. int. Pharmacodyn. v.163 Some Pharmacological Effects of Schizandra chinensis Volicer, L.(et al.)