Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effect of Benincasae Semen on Methylmercury-Induced Myotoxicity in Cultured Myocardial Cells

메틸수은으로 손상된 배양 심근세포에 대한 동과자의 영향

  • Ha Dae Ho (School of Medicine, Wonkwang University) ;
  • Yang Hyun Woong (School of Medicine, Wonkwang University, Institute of Wonkwang Medical Science, Wonkwang University) ;
  • Lee Kang Chang (Professional Graduate School of Oriental Medicine)
  • 하대호 (원광대학교 의과대학) ;
  • 영현웅 (원광대학교 의과대학, 원광의과학연구소) ;
  • 이강창 (원광대학교 한의학 전문대학원)
  • Published : 2003.10.01
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Abstract

To clerify the toxic effect of methylmercuric chloride(MMC) in cultured mouse myocardial cells, cytotoxic effect was measured by MTT assay after cultured myocardial cells were incubated for 48 hours in the media containing 1～30 uM concentrations of MMC. And also, the protective effect of Benincasae Semen (BS) was assessed in these cultrures. Cell viability was significantly decreased in a dose-dependent manner after cultured myocardial cells were exposed to 30 uM MMC for 48 hours. In the neuroprotective effect of BS on MMC-induced cytotoxicity, BS blocked the MMC-induced myotoxicity in these cultures. From these results, it suggests that MMC is toxic on cultured mouse myocardial cells and BS is effective in blocking the neurotoxicity induced by MMC.

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References

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