Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects of Herbal Compounds with Tuna bone Powder on Rodent Osteoporosis Model Induced by Ovariectomy

Ca 혼합처방인 SG 및 GN이 난소절제 백서의 골다공증에 미치는 영향 연구

  • Chi Gyoo Yong (Department of Pathology, College of Oriental Medicine) ;
  • Yoon Gun Ae (Department of Food Science and Nutrition, Dongeui University) ;
  • Kim Young Man (Department of Food Science and Nutrition, Dongeui University)
  • 지규용 (동의대학교 한의과대학 한의학과) ;
  • 윤군애 (동의대학교 생활과학대학 식품영양학과) ;
  • 김영만 (동의대학교 생활과학대학 식품영양학과)
  • Published : 2003.10.01
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Abstract

In this research 2 sample compounds are made and analyzed in terms of the in vivo and in vitro effects on the ovariectomized rats. The 2 compounds are prescribed based on pathologic patterns of osteoporosis, and added calcium citrate from tuna bone powder. SG is for menopausal women(Type I osteoporosis) and GN is for senile men(Type II osteoporosis). Through these, SG manifested Significant effects on the T4, osteocalcin level, and through the histological changes of osteoid tissues and lipocytes. On the other hand GN showed significant increase on the biochemical markers of osteocalcin, TALP, even in histological features and bone mineral density and intensity of femur it showed meaningful changes. But In the results of RT-PCR on the IL-1β, IL-6, TNF α, there weren't coherent results with in vivo test, that is they were increased in the sample compound group than control group. These increase of bone resorption was seemed that those cytokines had the osteoclasts promote their own resorptive functions after fragments of bone tissues were increased in the cavity. And this clearance of inner fragments help the bone to strengthen its own substance. Putting together above facts, the sample compounds, SG and GN, made of tuna bone powder and herbal solutions are predicted that there would be pharmacological actions improving the osteoporosis initiated from the disorders of calcic absorption and increase of bone resorption. And GN has more effective actions than SG at least in the animal model.

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References

  1. 노인의학 배철영;이영진(공저)
  2. Harrison's Principles of Internal Medicine 12th. ed. Wilson, J.(et al.)
  3. 대한약전 제7개정 의약품각조 대한약학대학협의회 약전분과회
  4. 가정의학회지 v.17 no.12 골다공증의 관련요인 윤수진;이균상;문호성
  5. Calcif Tissue Int. v.54 no.Sup.1 New developments in biochemical markers for osteoporosis Garneo, P.;Delmas, P.D.
  6. J. Bone Miner Res. v.11 no.3 Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis Garneo, P.;Sornay-Rendu, E.;Chapuy, M.C.;Delmas, P.D.
  7. 동의생리병리학회지 v.16 no.4 육린주가 난소적출 백서의 골다공증에 미치는 영향 최상순;엄주오;김송백;유심근
  8. J Bone Miner Res v.4 no.1 Characteristics of an ovariectomized osteopenic rat model Yamazaki, I.;Yamaguchi, H.
  9. Endocrinology v.134 Osteoblasts mediate thyroid hormone stimulation of osteoclastic bone resorption Britto, J.M.;Fenton, A.J.;Holloway, W.R.;Nicholson, G.C.
  10. Arch Int Med v.143 Exogenous hyperthyroidism with osteoporosis Fallon, M.D.;Perry, Ⅲ.;Bergfeld, M.;Droke, D.;Teitelbaum, S.L.;Abiolo, L.V.
  11. Arch Int Med v.146 Bone loss in hypothyroidism with hormone replacement: A histomorphometric study Coindre, J.M.;David, J.P.;Riviere, L.
  12. J Clinic Invest v.58 Direct stimulation of bone resorption by thyroid hormones Mundy, G.R.;Shapiro, J.L.;Bandelin, J.G.;Canalis, E.M.;Raisz, L.G.
  13. Rheumatology v.18 Biochemical marker of bone metabolism in osteoporosis Karaenzlin, M.E.
  14. 골다공증 김기수
  15. Am J Med v.103 Biochemical markers in the assessment of bone disease Bikle, D.D.
  16. N Eng J Med v.328 Effect of calcium supplementation of bone loss in postmenopausal women Reid, I.R.;Ames, R.W.;Evans, M.C.;Gamble, G.D.;Sharpe, S.J.
  17. N Eng J Med v.316 Does calcium supplementation prevent postmenopausal bone loss? Riis, B.;Thomsen, K.;Christiansen, C.
  18. Calcif Tissue Int v.40 Compressive strength, ash weight, and volume of vertebral trabecular bone in experimental fluorosis in pigs Mosekilde, Li;Kragstrup, J.;Richards, A.
  19. Orthopade v.30 no.7 Genetics of osteoporosis Gortz, B.;Fassbender, W.J.
  20. Endocr Rev v.20 no.6 Genetics of osteoporosis Eisman, J.A.
  21. Endocr Rev v.17 Advances in bone biology: The osteoclast Roodman, G.D.
  22. 골다공증 김기수
  23. Cytokine v.19 no.4 Hormonal modulation of interleukin-6, tumor necrosis factor and associated receptor secretion in postmenopausal women Brooks-Asplund, E.M.;Tupper, C.E.;Daun, J.M.;Kenney, W.L.;Cannon, J.G.
  24. Arch Intern Med. v.157 no.19 Estrogen replacement therapy and mortality among older women. The study of osteoporotic fractures Cauley, J.A.;Seeley, D.G.;Browner, W.S.;Ensrud, K.;Kuller, L.H.;Lipschutz, R.C.;Hulley, S.B.