Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects of Gamgung-tang Gamibang on 3,5,3-triiodothyronine-induced Hyperthyroidism in rats

감궁탕 가미방이 갑상샘기능장애에 미치는 효과

  • Choi Ho Seung (Department of Pathology, College of Oriental Medicine, Wonkwang University) ;
  • Kim Young Mok (Department of Pathology, College of Oriental Medicine, Wonkwang University) ;
  • Lim Jong Kook (Department of AM-Pointlogy, College of Oriental Medicine, Dongguk University) ;
  • Shon Yun Hee (Department of Pharmacology, College of Medicine, Dongguk University) ;
  • Nam Kyung Soo (Department of Pharmacology, College of Medicine, Dongguk University) ;
  • Kim Cheol Ho (Department of Biochemistry and Molecular Biology, College of Oriental Medicine, Dongguk University) ;
  • Jeon Byung Hun (Department of Pathology, College of Oriental Medicine, Wonkwang University)
  • 최호승 (원광대학교 한의과대학 병리학교실) ;
  • 김영목 (원광대학교 한의과대학 병리학교실) ;
  • 임종국 (동국대학교 한의과대학 경혈학교실) ;
  • 손윤희 (동국대학교 의과대학 약리학교실) ;
  • 남경수 (동국대학교 의과대학 약리학교실) ;
  • 김철호 (동국대학교 한의과대학 생화학 및 분자생물학교실) ;
  • 전병훈 (원광대학교 한의과대학 병리학교실)
  • Published : 2003.06.01
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Abstract

In this study, the effects of Gamgung-tang gamibang on the hyperthyroidism induced by the intraperitoneal injection of 3,5,3-triiodothyronine was examined by the measurement of physical changes, body weight, the volume of food intake and rectal temperature, and heart weight, heart beat, blood pressure with contrast to propranolol, one of beta-blocking agents. the obtained results were as follows. The Gamgung-tang gamibang extract showed to inhibit the decrease of body weight and rectal temperature, and decrease the food intake, so the inhibitory effects of Gamgung-tang gamibang extract on the experimental hyperthyroidism were exhibited. The Gamgung-tang gamibang extract showed the inhibitory effects on the circulatory functions changed and enhanced by the experimental induced hyperthyroidism, the action of Gamgung-tang gamibang extract was less effective than the propranolol of D-CONT group. The Gamgung-tang gamibang extract showed significant effects to inhibit the concentration of serum thyroid houmone, more effective than the propranolol, beta-blocking agents. The Gamgung-tang gamibang extract showed the effective inhibitory reaction on the biochemical changes in serum, cholesterol, ketone bodies, free fatty acid, glucose in hyperthyroid rats induced by 3,5,3-triiodothyronine.

Keywords

References

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