Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effect of Alii Macrostemi Bulbus on Cultured Mouse Osteoblasts Damaged by Reactive Oxygen Species

활성산소로 손상된 골모세포에 대한 해백의 영향

  • Son Il Hong (School of Medicine Wonkwang University, Institute of Wonkwang Science) ;
  • Yang Hyun Woong (School of Medicine Wonkwang University) ;
  • Lee Jai Kyoo (School of Medicine Wonkwang University) ;
  • Lee Kang Chang (Department of Graduate School of Oriental Medicine, Wonkwang University)
  • 손일홍 (원광대학교 의과대학, 원광의과학연구소) ;
  • 양현웅 (원광대학교 의과대학) ;
  • 이재규 (원광대학교 의과대학) ;
  • 이강창 (원광대학교 한의학전문대학원)
  • Published : 2003.06.01
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Abstract

It has been demonstrated that oxidative stress of reactive oxygen species(ROS) may be a causative factor in the pathogenesis of bony disorder. The purpose of this study was to evaluate the oxidative stress of glucose oxidase(GO) in the cultured mouse osteoblasts and the protective effect of Alii Macrostemi Bulbus(AMB) on ROS-induced osteotoxicity. Toxic effect of GO and protective effect of AMB were carried out by colorimetric assay. 20mU/mi GO decreased cell viability dose-dependently, and AMB increased cell viability against GO-induced cytotoxicity in these cultures. From above the results. GO has toxic effect, and AMB is very effective on GO-induced osteotoxicity in cultured osteoblasts of neonatal mouse.

Keywords

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