Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects of Ethanol-extract of Allium wageki on the Renal Function of Fructose-induced Hypertensive Rats

쪽파 에탄올 추출물이 과당 유도 고혈압 백서의 신장 기능에 미치는 영향

  • Kang Dae Gill (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee An Sook (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee Yun Mi (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Sohn Eun Jin (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Yeum Kee Bok (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee Ho Sub (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 강대길 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 이안숙 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 이윤미 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 손은진 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 염기복 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 이호섭 (원광대학교 한의학전문대학원 한약자원개발학과)
  • Published : 2003.04.01
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Abstract

The present study was aimed to investigate whether ethanol-extract of Allium wageki has an ameliorative effect on the renal function in high fructose-diet induced hypertensive rats .. The urine osmolality (Uosmol) was decreased in rats with high fructose-diet (60%) during the whole experiment period without change of the urine volume (UV). The urinary excretion of sodium (UNaV) and chloride (UCIV) were decrease significantly in rats with fructose-induced hypertensive rats, whereas urinary excretion of potassium (UKV) was Increased. The creatinine clearance (Ccr) and solute-free water reabsorption were also decreased by treatment of fructose-rich diet. Among these renal functional parameters, Ccr was partially restored by the administration of ethanol-extract of Allium wageki. The Uosmol was also partially restored by the administration ethanol-extract of Allium wageki at the end of the experimental period. Taken together, ethanol-extract of Allium wageki has the ameliorative effect on glomerular filtration rate in rats with high fructose-diet induced hypertension.

Keywords

References

  1. 도해 향약대사전 정보섭;신민교
  2. 완역 중약대사전 v.9 김창민(외)
  3. J. Pharmacol. Toxicol. Methods v.33 Fructose-induced hypertension in rats is concentration- and duration-dependent. Dai, S.;McNeill, J.H. https://doi.org/10.1016/1056-8719(94)00063-A
  4. Am. J. Hypertens. v.9 Defective endothelium-dependent relaxation in fructose-hypertensive rats. Verma, S.;Bhanot, S.;Yao, L.;McNeill, J.H. https://doi.org/10.1016/0895-7061(95)00392-4
  5. Metabolism v.50 Increased vascular endothelin-1 gene expression with unaltered nitric oxide synthase levels in fructose-induced hypertensive rats. Lee, D.H.;Lee, J.U.;Kang, D.G.;Paek, Y.W.;Chung, D.J.;Chung, M.Y. https://doi.org/10.1053/meta.2001.19527
  6. Hypertens. v.23 Vanadyl sulfate prevents fructose-induced hyperinsulinemia and hyper¬tension in rats. Bhanot, S.;McNeill, J.H.;Bryer-Ash, M. https://doi.org/10.1161/01.HYP.23.3.308
  7. 생약학회지 v.33 no.4 쪽파 에탄올 추출물이 과당유도 高血壓 흰쥐에 미치는 영향 강대길;손은진;이안숙;이윤미;유명호;노숙연;이호섭
  8. 生理學 김종규
  9. 장부변증논치 김완희;최달영
  10. 대한한의학회지 v.8 no.1 신기능에 대한 동서의학적 고찰 유도곤;이호섭;강순수;정우열
  11. 人體生理學 김광진;김창주;김형진;박사훈
  12. 전정판 腎臟學 서울대학교 의과대학
  13. Kidney Int. v.57 no.4 Diminished adenylate cyclase activity and aquaporin 2 Kim, SW.;Jeon, Y.S.;Lee, J.U.;Kang, D.G.;Kook, H.;Ahn, K.Y.;Kim, S.Z.;Cho, K.W.;Kim, N.H.;Han, J.S.;Choi, K.C. https://doi.org/10.1046/j.1523-1755.2000.00008.x
  14. J. CIin. Invest. v.99 no.7 Upregulation of aquaporin-2 water channel expression in chronic heart failure rat. Xu, D.L.;Martin, P.Y.;Ohara, M.;St John, J.;Pattison, T.;Meng, X.;Morris, K.;Kim, J.K.;Schrier. R.W. https://doi.org/10.1172/JCI119312
  15. J. Biol. Chem. v.263 no.21 Tissue-specific and developmental regulation of rat Na,K-ATPase catalytic alpha isoform and beta subunit mRNAs. Orlowski, J.;Lingrel, J.B.
  16. J. Biol. Chem. v.269 no.38 The alpha-subunit of the Na,K-ATPase has catalytic activity independent of the beta-subunit. Blanco, G.;DeTomaso, A.W.;Koster, J.;Xie, Z.J.;Mercer, R.W.
  17. Proc. Nati. Acad. Sci. v.91 no.18 The alpha subunit of the Na, K-ATPase specifically and stably associates into oligomers. Blanco, G.;Koster, J.C.;Mercer, RW. https://doi.org/10.1073/pnas.91.18.8542
  18. Exp. Nephrol. v.5 no.6 Expression of Na(+)-H+ exchanger isoforms NHE1 and NHE3 in kidney and blood cells of rabbit and rat. Rutherford, P.A.;Pizzonia, J.H.;Biemesderfer, D.;Abu-AHa, A.;Reilly, R.;Aronson P.S.
  19. Am. J. Physiol. v.273 no.2 Monoclonal antibodies for high-resolution localization of NHE3 in adult and neonatal rat kidney. Biemesderfer, D.;Rutherford, P.A.;Nagy, T.;Pizzonia, J.H.;Abu-Alfa, A.K.;Aronson, P.S. https://doi.org/10.1152/ajpcell.1997.273.1.C289
  20. Am. J. Physiol. v.276 no.1 Vasopressin increases Na-K-2Cl co transporter expression in thick ascending limb of Henle's loop. Kim, G.H.;Ecelbarger, C.A.;Mitchell, C.;Packer, R.K.;Wade, J.B.;Knepper, M.A.
  21. Kidney Int. v.50 no.1 Localization of the thiazide sensitive Na-Cl co transporter, rTSC1 in the rat kidney. Plotkin, M.D.;Kaplan, M.R.;Verlander, J.W.;Lee, W.S.;Brown, D.;Poch, E.;Gullans, S.R.;Hebert, S.C. https://doi.org/10.1038/ki.1996.300
  22. J. Clin. Invest. v.104 no.7 Aldosterone-mediated regulation of ENaC alpha, beta, and gamma subunit proteins in rat kidney. Masilamani, S.;Kim, G.H.;Mitchell, C.;Wade, J.B.;Knepper, M.A. https://doi.org/10.1172/JCI7840