Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Screening of Cytotoxicity and Antimicrobial Effects of Hexane Extracts from Cornis fructus

산수유 헥산 추출물의 항균효과 및 세포독성

  • Chun Hyun Ja (Division of Natural Science, Wonkwang University) ;
  • Choi Won Hyung (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee Jeong Ho (Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Yang Hyun Ok (Department of Cosmetic, Wonkwang Health Science) ;
  • Baek Seung Hwa (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 천현자 (원광대학교 자연과학기술학부) ;
  • 최원형 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 이정호 (원광대학교 한의학전문대학원 제3의학과) ;
  • 양현옥 (원광보건대학 피부미용학과) ;
  • 백승화 (원광대학교 한의학전문대학원 한약자원개발학과)
  • Published : 2003.04.01
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Abstract

Cornis fructus was extracted by successive extraction and then fractionated with hexane extract to get active fractions. This study was performed to determine the cytotoxic effect of hexane extract from Cornis fructus on NIH 3T3 fibroblasts and cancer cell lines using MTT assay. Hexane extract showed cytotoxic effect against A549, B16 melanoma and MDA-MB-231. Futher fractionation with hexane extract was performed to obtain effective fraction, fraction 3 showed the cytotoxic effect against A549 and MDA-MB-231. In antimicrobial test of each fraction of hexane extract, fraction 5 showed antimicrobial activities against P. putida and P. aeruginosa.

Keywords

References

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