Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effects of Mangeum-tang and Gamimangeum-tang on the Cultured Spinal Dorsal Root Ganglion Cells

만금탕 및 가미만금탕이 배양 척수후근신경절 세포에 미치는 영향

  • Choi Gyu Seon (Department of Oriental Rehabilitation Medicine, Collage of Oriental Medicine, Wonkwang University) ;
  • Yun Sang Hak (Department of Oriental Rehabilitation Medicine, Collage of Oriental Medicine, Wonkwang University) ;
  • Yeom Seung Ryong (Department of Oriental Rehabilitation Medicine, Collage of Oriental Medicine, Wonkwang University) ;
  • Lee Su kyung (Department of Oriental Rehabilitation Medicine, Collage of Oriental Medicine, Wonkwang University) ;
  • Shin Byung Cheul (Department of Oriental Rehabilitation Medicine, Collage of Oriental Medicine, Wonkwang University) ;
  • Kwon Young Dal (Department of Oriental Rehabilitation Medicine, Collage of Oriental Medicine, Wonkwang University) ;
  • Song Yung Sun (Department of Oriental Rehabilitation Medicine, Collage of Oriental Medicine, Wonkwang University)
  • 최규선 (원광대학교 한의과대학 한방재활의학과교실) ;
  • 윤상학 (원광대학교 한의과대학 한방재활의학과교실) ;
  • 염승룡 (원광대학교 한의과대학 한방재활의학과교실) ;
  • 이수경 (원광대학교 한의과대학 한방재활의학과교실) ;
  • 신병철 (원광대학교 한의과대학 한방재활의학과교실) ;
  • 권영달 (원광대학교 한의과대학 한방재활의학과교실) ;
  • 송용선 (원광대학교 한의과대학 한방재활의학과교실)
  • Published : 2003.04.01
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Abstract

The purpose of this study is to examine the toxic effects caused by xanthine oxidase/hypoxanthine (XO/HX) and the effects of herbal extracts such as Mangeum-tang (萬金湯: MGT) and Gamimangeum-tang (加味萬金湯: GMGT) on the treatment of the toxic effects. The results of these experiments were XO/HX, an oxygen radical-generating system, decreased the survival rates of the cultured cells on XTT assay, the amount of DNA syntheses, and the amount of neurofilaments, and increased c-fos positive cells, MGT and GMGT have the efficacy of increasing the survival rates of the cultured cells by increasing the amount of neurofilaments and DNA synthesis and decreasing the c-fos positive cells damaged by XO/HX, From the above results, it is suggested that MGT and GMGT have marked efficacy as a treatment for the damages caused by the XO/HX-mediated oxidative stress. And MGT and GMGT are thought to have certain pharmacological effects.

Keywords

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