Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Studies on a New Alimentotheraphy for Ddiabetic Patients

당뇨환자를 위한 새로운 식이요법제에 관한 연구

  • Published : 2003.02.01
Download PDF
⟨ Previous Next ⟩

Abstract

Mulberry, Mori folium leaves (ML) and fruits (MF), Lycii fructus (LF), and Panax ginseng have been known to maintain normal blood sugar levels (BSL) in folk medicine. Here we investigated the effects of coated rice with these herb extract to diabetic patients. Alloxan-induced diabetes mellitus (DB) mice (80 mg/kg BW., i.v.) separated into 3 groups. One group received the extract in high dose (6.5 mg/kg B.W.), and another one group received in low dose (1.3 mg/kg B.W.) perorally for 30 days. (+) control received no extracts. (-) control received neither of them. BSL, volume of water consumed (VWC), body weights (BW) of each group were measured and compared. BSL in both of the extracts-received groups got close to normal levels on 4th week after starting the experiments. VWC also showed the same pattern. BSL in (+) control remained high through the experiment periods. BW in (+) control remained high, but those in the extracts-received groups recovered to normal levels. The clinical trials for both of healthy volunteers and DB patients, conducted in a University Hospital, also showed that the rice coated with the extracts could control the BSL. From these results, we suggest that the functional rice with herb extracts could be used as a new alimentotherapy for DB patients.

Keywords

References

  1. 당뇨병학 제 1장 당뇨병의 최근 개념 대한당뇨학회
  2. Scientific America v.52 no.suppl.1 What cause diabetes? Atkinson M.A.;Maclaren N.K.
  3. Diabetes. v.43 Insulin action, diabetogenes, and the cause of type Ⅱ diabetes. Kahn Y.H. https://doi.org/10.2337/diab.43.8.1066
  4. 당뇨병학 제 31장 경구 혈당강하제 대한당뇨병학회
  5. 당뇨병 치료제의 검색방법 전통약물로부터 신약개발연구법 정성현
  6. 약학회지 v.38 no.5 소갈증 치료제가 실험적 당뇨 흰쥐에 미치는 영향 - 총심연자음, 가미위승기탕, 기국지황탕 이인자;이다미
  7. 약학회지 v.39 no.4 상엽의 혈당강하 활성 이주선;최명현;정성현
  8. 생약학회지 v.23 no.2 혈당 강하 작용 식물의 검색(1). 김옥경;이은방
  9. 생약학회지 v.24 no.3 두릅나무 근피의 혈당강하 성분에 관한 연구(1)-MeOH엑스 및 분획물의 혈당강하작용. 이은방;김옥경
  10. 생약학회지 v.25 no.3 당뇨유발쥐에서 닭의장풀의 혈당감소효과와 간조직내의 Glucose-6-phosphate Dehydrogenase의 효소활성에 미치는 효과. 박수영;조경혜
  11. A Folk Remedy.(1st Ed.) Ahn DG.
  12. A Folk Remedy(1st Ed.) Ahn DG.
  13. Diabetes Mellitus Diary.(7st Ed.) Choue Y A.
  14. A monthly Diabetes Magazine v.5 Popular Food, Harmfutness Food. A Folk Oriental Medicine Remedy for subject. Heo GY.
  15. Diabetes v.18 no.3 A study on the folk remedies by the questionaries in Korean diabetic patients. Nam MS;Kim KR, Cho JH;Lee KM; Park HY;Lee EJ;Lim SK;Lee HC; Huh KB.
  16. Biochem Pharmacol v.50 Differential effects of in vitro peroxidation on peripheral-and centrol-type benzodiazepine receptor. Protection by diverse antioxidants. Courtiere A.;Molard F.;Reyband J. https://doi.org/10.1016/0006-2952(95)02058-6
  17. J. Korean Soc. Food Sci. Nutr. v.31 no.5 YK-209 뽕잎이 Streptozocin 유발 당뇨쥐 간조직에서의 HMG-CoA Reductase 활성과 지질조성에 미치는 영향. https://doi.org/10.3746/jkfn.2002.31.5.826
  18. Kor. J. Pharmacogn. v.31 no.2 석이에서 분리한 GE974의 ${\alpha}$-Glucosi-dase 저해효과 최혁재;김남재;김동현
  19. Chromatograrhy A Jin Won Kim;Kang Sun Ryu.
  20. 의약품 등 기준 및 시험방법. 제 2개정. 식약청 고시
  21. Korean J. Food Sci. Technol. v.22 no.7 메밀 및 메밀 식품에서의 루틴 분석 맹영선;박혜경;권태봉
  22. 한국영양학회지 v.31 no.2 고탄수화물 식이 섭취 마우스에서 상엽 및 누에 추출물의 혈당강하 효과. 김미선;조여원;정성현;구성자
  23. J. Korean Soc. Food Nutr. v.15 no.2 Effects of Lycii fructurs extract on experimentally induced liver damage and allozan diavetes in rabbits. Hwa-Joong Sheo;Sung-Joo Jun;Myung-Yul Lee
  24. Kor. J. Pharmacogn. v.25 no.3 Pharmacological effects of Lycium chinensis. Nam Jae Kim;Whang Geum Youna; Nam Doo Hong.
  25. Agric. biol. Chem. v.52 no.1 Inhibition of intestinal ${\alpha}$-glucosidase activity and postprandial hyper-glycemia by moranoine and its N-alkylated deribates. Yoshikuni Y.
  26. Methods in Plant Biochemistry. Flavones, flavonols and their glycosides. Markham KR.
  27. 응용약물학회지 v.6 구기자 성분의 혈당강하작용. 김경순;실상희;정기화;정춘식;고광호;박정일;허훈;이봉진;김박광
  28. Korean J. Seric. Sci. v.39 no.1 An activity of lowering blood-glucose levels according to preparative conditions of silkworm powder. Kang Sun Ryu;Heui Sam Lee;Sung Hyun Chung;Pil Don Kang.
  29. 석사학위 논문 Change in physicochemical properties of korean mume(Jananese apricot, Prunus mume Sieb. et Zucc) ftuits during maturation and storage. 차환수
  30. Horm. Metab. Res. v.30 Potentiation of glucose-induced insulin secretion by fagomine, a pseudo-sugar isolated form Mulberry leaves. S. Taniguch;N. Asano;F. Tomino;I. Miwa. https://doi.org/10.1055/s-2007-978957