Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Biological activity of an Indian medical plant, Indigofera cordifolia

  • Rao, Bhattiprolu Kesava (Department of Chemistry, Nagarjuna University) ;
  • Kawase, Masami (Faculty of Pharmaceutical Sciences, Josai University) ;
  • Tanaka, Toru (Faculty of Pharmaceutical Sciences, Josai University) ;
  • Tani, Satoru (Faculty of Pharmaceutical Sciences, Josai University) ;
  • Motohashi, Noboru (Meiji Pharmaceutical University) ;
  • Satoh, Kazue (School of Medicine, Showa University) ;
  • Sakagami, Hiroshi (Department of Dental Pharmacology, Meikai University School of Dentistry) ;
  • Terakubo, Shigemi (Department of Microbiology, St. Marianna University School of Medicine) ;
  • Nakashima, Hideki (Department of Microbiology, St. Marianna University School of Medicine) ;
  • Wolfard, Krisztina (Faculty of Medicine, Institute of Medical Microbiology, Albert Szent-Gyorgyi Medical Centrum, University of Szeged) ;
  • Molnar, Joseph (Faculty of Medicine, Institute of Medical Microbiology, Albert Szent-Gyorgyi Medical Centrum, University of Szeged)
  • Published : 2004.09.30
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Abstract

The ethanol extract of Indigofera cordifolia was studied for in vivo gastroprotective activity, cytotoxic activity against oral tumor and normal cells, multidrug resistance (MDR) reversal activity, anti-human immunodeficiency virus (HIV) activity and radical scavenging activity. The extract of I. cordifolia showed potent gastric mucosal protective activity against stomach injury induced by HCl/EtOH solution. However, the gastroprotective activity could not be related to the radical mechanism, because the extract weakly scavenged both OH radical and $O_2*^-$. The extract also showed promising levels of MDR-reversing activity. This study demonstrates the tumor-specific cytotoxic action of the plant extract. However, the extract had no anti-HIV activity. From above results, the study suggests the medicinal importance of I. cordiforia extract.

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References

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