Advances in Traditional Medicine

  • 제4권4호
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  • Pages.253-260
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  • 2004
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  • 2662-4052(pISSN)
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  • 2662-4060(eISSN)
경희대학교 융합한의과학연구소 (Kyung Hee Oriental Medicine Research Center)
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Gastroprotective effect of zosterin, a pectin from seagrass ZOSTERA MARINA L.

  • Khasina, Eleonora I. (Laboratory of Pharmacology, Institute of Marine Biology, Far East Branch of the Russian Academy of Sciences) ;
  • Tiupeleev, Piotr A. (Laboratory of Pharmacology, Institute of Marine Biology, Far East Branch of the Russian Academy of Sciences) ;
  • Sgrebneva, Marina N. (Laboratory of Pharmacology, Institute of Marine Biology, Far East Branch of the Russian Academy of Sciences)
  • 발행 : 2004.12.30
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초록

Zosterin is a pectin from a seagrasses of the family Zosteraceae. Zosterin was given to rats intragastrically once 1h before the emotional stress or injection of indomethacin, or administration of 2, 4-D solution daily for seven days at dose of 100 mg/kg. The data obtained demonstrate that zosterin enhances resistance of the stomach tissue to various ulcerogenic factors (emotional stress, indomethacin, pesticide 2, 4-D). It was shown to possess a gastroprotective effect, which is accompanied by diminution of the number and sizes of destructive regions in the gastric mucosa during the ulcer affection, as well as reduction of ATP and glycogen deficit, decrease of lactate excess, and normalization of the energy balance in the gastric mucosa. According to its antiulcer effect, zosterin may be recommended for application in prevention and treatment of stomach diseases together with the basic therapy.

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참고문헌

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