Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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A protective effect of the methanol extract of Shelliguea feei METT. roots on gastric ulcers in mice and rats

  • Subarnas, Anas (Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Padjadjaran University) ;
  • Herdiana, Yana (Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Padjadjaran University) ;
  • Sriwidodo, Sriwidodo (Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Padjadjaran University) ;
  • Dianti, Ajeng (Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Padjadjaran University)
  • Published : 2004.12.30
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Abstract

A protective effect of the methanol extract of Shelliguea feei METT. roots on gastric lesions induced by stress in mice and HCl/ethanol in rats has been investigated. Animals were randomly divided into control and test groups and given the methanol extract orally at doses of 0.5, 1.0, and 2.0 g/kg of body weight. This investigation indicated that the methanol extract at doses of 1.0 and 2.0 g/kg significantly reduced stress-induced gastric lesions in mice at the percent protection of 38% and 62%, respectively, and decreased the number of HCI/ethanol-induced ulcers in rats significantly at the percent inhibition of 21.50% and 90.65%, respectively, and severity of ulcers at the score of 3.6 and 1.0 significantly different from the control. These results suggest that the methanol extract of S. feei may have a beneficial protective effect on the gastric ulcers.

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References

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