Journal of Chest Surgery

The Korean Society for Thoracic and Cardiovascular Surgery (대한심장혈관흉부외과학회)
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Surgical Resection of Solitary Fibrous Tumors of the Pleura

고립성 섬유성 흉막 종양의 수술적 절제

  • 장지원 (제주대학교병원 흉부외과) ;
  • 김관민 (성균관대학교 삼성서울병원 흉부외과) ;
  • 심영목 (성균관대학교 삼성서울병원 흉부외과) ;
  • 한정호 (성균관대학교 삼성서울병원 병리과) ;
  • 이경수 (성균관대학교 삼성서울병원 영상의학과) ;
  • 김진국 (성균관대학교 삼성서울병원 흉부외과)
  • Published : 2004.05.01
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Abstract

Background : Solitary fibrous tumors of the pleura (SFTP) is one of rare neoplasms that originated from submesothelial mesenchyme. Clinical course or extent of surgical resection is not well known. Material and Method: We retrospectively reviewed all the clinical records of the patients who had undergone surgical resection of benign and malignant SFTP, Result: Twenty two (male female 14 : 8) patients were enrolled and mean age was 50.2(range 25∼83). Number of symptomatic patients at the time of diagnosis was 13 (59%) and the most common symptom was dyspnea. Operative approach was carried out through thoracotomy (n=14) or video-assisted thoracic surgery (n=8). Mass excision was performed in 12 cases and en bloc resection including adjacent structure in 10 cases. In all cases complete resection was performed. There was no operative mortality. Malignant SFTP were 11 cases and benign SFTP 11 cases. Local recurrences (n=2) or distant metastasis (n=6) occurred only in malignant SFTP. Conclusion: Number of symptomatic patients, on bloc resection, and recurrence was more in malignant SFTP. Although complete surgical resection is known as treatment of choice for SFTP, further study should be performed about systemic therapeutic modalities pre- or postoperatively to control recurrence and metastasis.

배경 : 고립성 섬유성 흉막 종양(SFTP)은 중피하 중간엽에서 기원한 매우 드문 종양으로, 임상 경과나 적절한 수술적 절제의 범위 및 추적 관찰 결과 등에 대해 알려진 바가 매우 제한적이다. 대상 및 방법: 9년간(1994∼2003) 양성 및 악성 고립성 섬유성 흉막 종양으로 수술적 절제를 받은 환자를 대상으로 후향적 연구를 시행하였다. 결과: 총 22명의 환자(남 14, 여 8)가 포함되었고 평균 연령은 50.2세 (25∼83세)였다. 진단 당시 증상을 나타낸 환자는 13명(59%)이었고 가장 흔한 증상은 호흡 곤란이었다. 개흉술이 14예, 비디오 흉강경을 이용한 수술이 8예에서 행해졌으며, 종괴만을 절제한 경우는 12예, 주변 구조물을 포함한 광범위 절제를 행한 경우는 10예였다 모든 경우에 완전 절제술이 가능하였으며 수술 사망은 없었다. 수술 후 병리학적 진단 결과 양성 종양이 11예, 악성 종양이 11예였다. 추적 관찰 중 국소 재발 2예, 전신 전이가 6예에서 있었으며 재발과 전이는 모두 악성에서만 발생하였다. 결론: 진단 당시 증상이 있는 환자, 광범위 절제술, 재발 등은 모두 악성형에서 유의하게 많았다. 아직까지는 수술적 완전 절제가 가장 적절한 치료로 알려져 있으나, 재발과 전이를 억제하기 위한 수술 전후 전신 치료의 방법에 대해서 더 많은 연구가 필요할 것으로 생각된다.

Keywords

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