Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
권호 표지

Single Oral Dose Toxicity Study of Balbusae caulis in Taeniam in Rats

랫드에서 죽여(Balbusae caulis in Taeniam)의 단회경구투여 독성시험

  • Published : 2004.09.01
Download PDF
⟨ Previous Next ⟩

Abstract

The present study was carried out to investigate the potential acute toxicity of Balbusae caulis in taeniam by a single oral dose in Sprague-Dawley rats. Twenty rats of each sex were randomly assigned to four groups of 5 rats each and were administered singly by gavage at dose levels of 0, 1250, 2500, and 5000 mg/kg body weight. Mortalities, clinical findings, and body weight changes were monitored for the 14-day period following administration. At the end of 14-day observation period, all animals were sacrificed and complete gross postmortem examinations were per-formed. Throughout the study period, no treatment-related deaths were observed. There were no adverse effects on clinical signs, body weight, and gross finding at any dose tested. The results showed that the single oral administration of Balbusae caulis in taeniam did not cause any toxic effect at the dose levels of 5000 mg/kg or lower in rats and the minimal lethal dose was considered to be over 5000 mg/kg body weight for both sexes.

Keywords

References

  1. 명성하, 이학인, 김연섭 (1999): 죽여와 나국자가 실험적 당뇨에 미치는 영향. 대한본초학회지, 14, 79-86
  2. 식품의약품안전청 (1999): 의약품등의 독성시험기준. 식품의약품 안전청고시 제1999-61호, 서울
  3. 호희명 (1993): 중국한의비방대전. 서원당, 서울,pp. 347
  4. Flood, M.T. and Kondo, M. (2003): Safety evaluation of lipase produced from Rhizopus oryzae: summary of toxicological data. Regul. Toxicol. Pharmacol., 37, 293-304
  5. Hodge, H.C. and Sterner, J.H. (1949): Tabulation of toxicity classes. Am. Ind. Hyg. Q., 10, 93
  6. Hu, C., Zhang, Y. and Kitts, D.D.J. (2000). Evaluation of antioxidant and prooxidant activities of bamboo Phyllostachys nigra var. henonis leaf extract in vitro. Agric. Food Chern., 48, 3170-3176 https://doi.org/10.1021/jf0001637
  7. Munro, I.C., Kennepohl, E. and Kroes, R. (1999): A procedure for the safety evaluation of flavoring substances. Food Chem. Toxicol., 37, 207-232.
  8. Kim, N.K., Cho, S.H. and Lee, S.D. (2001): Functional properties and antimicrobial activity of bamboo (Phyllostachys spp.) extracts. Kor. J. Posthsrvest Sci. Technol., 8, 475-480
  9. Kim, J.C., Kang, B.H., Shin, C.C., Kim, Y.B., Lee, H.S., Kim, C.Y., Han, J., Kim, G.S., Chung, D.W and Chung, M.K. (2002): Subchronic toxicity of plant sterol esters administered by gavage to Sprague-Dawley rats. Food Chem. Toxicol., 40,1569-1580.
  10. Kim, J.C., Shin, D.H., Ahn, T.H., Kang, S.S., Song, S.W., Han, J., Kim, C.Y., Ha, C.S. and Chung, M.K. (2003): 26Week oral repeated dose toxicity study of the new quinolone antibacterial DW-116 in Sprague-Dawley rats. Food Chem. Toxicol., 41, 637-645.
  11. Okabe, S., Takeuchi, K., Takagi, K. and Shibata, M. (1975): Stimulatory effect of the water extract of bamboo grass (Folin solution) on gastric acid secretion in pylorus-ligated rats. Jpn. J. Pharmacol., 25, 608-609
  12. Rajebhosale, VA, Burte, R.G. and Toro, VA (1998): Nutritive value of bamboo (Dendrocalamus calostachyus) leaves for crossbred calves. Ind. J. Anirn. Nutr., 15, 58-60
  13. Shibata, M., Yamatake, M., Sakamoto, M., Kanamori, K., Takagi, K. and Okabe, S. (1975): Pharmacological studies on bamboo grass. Nippon Yakurigaku Zasshi, 71,481-485 https://doi.org/10.1254/fpj.71.481
  14. Shibata, M., Sato, F., Takeshita, K. and Otani, K. (1980): Pharmacological studies on bamboo grass Sasa-albomarginata 5. Combined effects of the extract F-D with vitamin C. Shoyakugaku Zasshi, 34, 274-279
  15. Son, WC. (2003): Analysis of fighting-associated wounds causing death of young male CD-1 mice in carcinogenicity studies. Scand. J. Lab. Anirn. Sci., 30, 101-111
  16. Tsunoda, S., Yamamoto, K., Sakamoto, S., Inoue, H. and Nagasawa, H. (1998): Effects of Sasa Health, extract of bamboo grass leaves, on spontaneous mammary tumourigenesis in SHN mice. Anticancer Res., 18, 153-158
  17. US Environmental Protection Agency. (1998): Health Effects Test Guidelines OPPTS 870.1100, Acute Oral Toxicity. U.S. Government Printing Office, Washington, DC
  18. Wolf, B.W and Weisbrode, S.E. (2003): Safety evaluation of an extract from Salacia oblonga. Food Chem. Toxieol., 41, 867-874.