Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Protective Effects Wonjiseokchangpo-san has on Brain Damage and Cognitive Dysfunction in Transient Focal Cerebral Ischemia

일시적 국소 뇌허혈 흰쥐모델에서 원지석창포산의 뇌손상 및 인지기능 보호효과

  • Kang Mi Sun (Department of Pediatrics, College of Oriental Medicine, Dongguk University) ;
  • Chang Gyu Tae (Department of Pediatrics, College of Oriental Medicine, Dongguk University) ;
  • Kim Jang Hyun (Department of Pediatrics, College of Oriental Medicine, Dongguk University)
  • 강미선 (동국대학교 한의과대학 소아과학교실) ;
  • 장규태 (동국대학교 한의과대학 소아과학교실) ;
  • 김장현 (동국대학교 한의과대학 소아과학교실)
  • Published : 2004.12.01
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Abstract

This study was conducted to determine the effects Wonjiseokchangpo-san on brain damage in transient focal cerebral ischemia. Rats were used for testing in the following three models: Morris Water Maze, Eight-Arm Radial Maze, and Histochemistry. In the Morris Water Maze Model, the Wonjiseokchangpo-san group showed significant decrease in the 3rd and 6th training session compared with the ischemia group. A retention test, in the Morris Water Maze Model, was performed on the 7th day without the escape platform. The Wonjiseokchangpo-san group showed significant increase compared to the ischemia group. In the Eight-Arm radial Maze model, the Wonjiseokchangpo-san group showed significant decrease in the error rate compared to the ischemia group. In the density of hippocampal CA1 cell of the cresyl violet-stained section, the Wonjiseokahangpo-san group showed significant increase compared to the ischemia group. These results suggest that Wonjiseokchangpo-san may have a significant protective effect on brain damage and cognitive dysfunction in transient focal cerebral ischemia.

Keywords

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