Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects of the Ethyl Acetate Soluble Fractions of Sophorae Radix In Langendorff Hearts

고삼 Ethyl Acetate 소분획이 적출 심장에 미치는 영향

  • Kwon Kang Beom (Department of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Park Gwan Ha (Department of Marine Biomedical Science, College of Ocean Science of Technology, Kunsan National University) ;
  • Kim Woo Kyung (Department of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Kim Eun Kyung (Department of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Kim Goo Hwan (Department of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Ko Kwang Hak (Department of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Choi Yeon Seong (Department of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Zhang Geun Gook (Department of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Rho Seong Il (Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Han Dong Won (Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Cha Suk (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Park Dae Young (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Ryu Do Gon (Department of Physiology, College of Oriental Medicine, Wonkwang University)
  • 권강범 (원광대학교 한의과대학 생리학교실) ;
  • 박관하 (군산대학교 해양과학대학 해양생명의학과) ;
  • 김우경 (원광대학교 한의과대학 생리학교실) ;
  • 김은경 (원광대학교 한의과대학 생리학교실) ;
  • 김구환 (원광대학교 한의과대학 생리학교실) ;
  • 고광학 (원광대학교 한의과대학 생리학교실) ;
  • 최연성 (원광대학교 한의과대학 생리학교실) ;
  • 장근국 (원광대학교 한의과대학 생리학교실) ;
  • 노성일 (원광대학교 한의과대학 재활의학교실) ;
  • 한동원 (원광대학교 한의과대학 재활의학교실) ;
  • 차숙 (원광대학교 한의과대학 간계내과학교실) ;
  • 박대영 (원광대학교 한의과대학 간계내과학교실) ;
  • 류도곤 (원광대학교 한의과대학 생리학교실)
  • Published : 2004.10.01
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Abstract

We previously reported that the ethtyl acetate(EA) soluble fraction of Sophorae Radix(SR) water extract had the preventive effects against cardiovascular anaphylaxis elicited in experimental animals. In this study, we tested the anti-anaphylatic effects of the nine kinds of EA soluble subfractions in animal models such as Langendorff heart and anesthetized rats. These results were obtained as followed ; Among nine kinds of SR EA soluble subfractions, N10-16-2 and N10-16-9 fractions have an effects improving cardiovascular anaphylaxis in guinea pig Langendorff hearts. In passively anesthetized rats, N10-16-2 and N1 0-16-9 fractions of SR EA soluble subfractions have an effects improving cardiovascular anaphylaxis. N10-16-2 and N1 0-16-9 fractions of SR EA soluble subfractions inhibited the decrease of histamine release induced by compound 48180 and A-23187 in rat peritoneal mast cells. These results suggest that N10-16-2 and N10-16-9 fractions of SR EA soluble subfractions involve anti-anaphylactic molecules in cardiovascular system.

Keywords

References

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