Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects of Gamimajeonojahwan Extract on the Sexual Function in Male Rats

가미마전오자환 추출물이 웅성 백서의 성기능에 미치는 효과

  • Kwon Kang Beom (Department of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Kim Bok Ryang (Department of Biochemistry, College of Medicine, Wonkwang University) ;
  • Hwang In Jin (Department of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Kim Eun Kyung (Department of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Kim Goo Hwan (Department of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Ko Kwang Hak (Department of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Choi Yeon Seong (Department of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Zhang Geun Gook (Department of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Ryo Seong Il (Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Han Dong Won (Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Cha Suk (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Park Dae Young (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Ryu Do Gon (Department of Physiology, College of Oriental Medicine, Wonkwang University)
  • 권강범 (원광대학교 한의과대학 생리학교실) ;
  • 김복량 (원광대학교 의과대학 생화학교실) ;
  • 황인진 (원광대학교 한의과대학 생리학교실) ;
  • 김은경 (원광대학교 한의과대학 생리학교실) ;
  • 김구환 (원광대학교 한의과대학 생리학교실) ;
  • 고광학 (원광대학교 한의과대학 생리학교실) ;
  • 최연성 (원광대학교 한의과대학 생리학교실) ;
  • 장근국 (원광대학교 한의과대학 생리학교실) ;
  • 노성일 (원광대학교 한의과대학 재활의학교실) ;
  • 한동원 (원광대학교 한의과대학 재활의학교실) ;
  • 차숙 (원광대학교 한의과대학 간계내과학교실) ;
  • 박대영 (원광대학교 한의과대학 간계내과학교실) ;
  • 류도곤 (원광대학교 한의과대학 생리학교실)
  • Published : 2004.10.01
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Abstract

To evaluate effect of Gamimajeonojahwan(GMOH) water extract on sexual functions, we orally administered GMOH exract(1,100㎎/㎏) for four weeks in male rats impaired by 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD) and ketoconazole(KZ). And we investigated the sexual behaviors such as mount latency, mount frequency, intromission latency, intromission frequency, ejaculation period and ejaculation latency. Serum testosterone concentrations also are evaluated in GMOH-and/or vehicle-treated male rats. The results were obtained as follows: GMOH inhibited the increase of intromission latency by TCDD in male rats. GMOH inhibited the decrease of intromission frequency by TCDD in male rats. GMOH inhibited the increase of ejaculation latency by TCDD in male rats. GMOH inhibited the decrease of serum testosterone concentration by TCDD in male rats. GMOH inhibited the decrease of serum testosterone concentration by KZ in male rats. These results suggest that GMOH water extract is active in improving sexual functions and protecting a decrease of testosterone concentrations induced by TCDD and KZ in male rats.

Keywords

References

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