동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)

  • 제18권5호
  • /
  • Pages.1418-1425
  • /
  • 2004
  • /
  • 1738-7698(pISSN)
  • /
  • 2288-2529(eISSN)
대한동의생리학회·한의병리학회 ( The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine)
권호 표지

베타 아밀로이드 유도성 Neuro 2A 세포독성에 대한 총명탕의 효과

Chongmyung-tang Inhibits the Cytotoxicity of Beta-amyloid in Neuro 2A Neuroblastoma Cells

  • 국윤재 (원광대학교 한의과대학 신경정신과학교실) ;
  • 최혁 (원광대학교 한의과대학 신경정신과학교실) ;
  • 김태헌 (원광대학교 한의과대학 신경정신과학교실) ;
  • 강형원 (원광대학교 한의과대학 신경정신과학교실) ;
  • 유영수 (원광대학교 한의과대학 신경정신과학교실)
  • Gug Yun Jai (Department of Neuropsychology, College of Oriental Medicine, Wonkwang University) ;
  • Choi Hyuk (Department of Neuropsychology, College of Oriental Medicine, Wonkwang University) ;
  • Kim Tae Heon (Department of Neuropsychology, College of Oriental Medicine, Wonkwang University) ;
  • Kang Hyung Won (Department of Neuropsychology, College of Oriental Medicine, Wonkwang University) ;
  • Lyu Young Su (Department of Neuropsychology, College of Oriental Medicine, Wonkwang University)
  • 발행 : 2004.10.01
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초록

The water extract of Chongmyung-tang has been traditionally used for treatment of memory-disorder in oriental medicine. This study was designed to investigate the protective mechanisms of Chongmyung-tang on β-amyloid or H₂O₂-induced cytotoxicity in Neuro 2A cells. The water extract of Chongmyung-tang significantly reduced both β-amyloid or H₂O₂-induced cell death and apoptotic characteristics through reduction of intracellular peroxide generation. Also, it inhibited the mitochondrial dysfunction including the disruption of mitochondria membrane permeability transition(MPT) and the modulation in expression of Bcl-2 family proteins in H₂O₂-treated H9c2 cells. Furthermore, pretreatment of quercetin inhibited the activation of caspase-3, in turn, degradation of ICAD/DFF45 were completely abolished in H₂O₂-treated cells. Taken together, that data suggest that the protective effects of the water extract of Chongmyung-tang against β-amyloid induced oxidative injuries may be achieved through modulation of mitochondrial dysfunction.

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참고문헌

  1. 編註醫學入門(卷二) 李천
  2. 增補萬病回春 공廷賢
  3. 大韓韓方內科學會誌 v.13 no.2 老人性 痴매에 대한 文獻的 考察 金賢兒
  4. 大韓針灸學會誌 v.14 no.1 痴매에 대한 東西醫學의 文獻的 考察 徐政烈(외)
  5. 東醫神經精神科學會誌 v.7 no.1 痴매에 대한 韓醫學的 臨床硏究 黃義完(외)
  6. ICD-10 정신 및 행동장애 분류 李符永(譯)
  7. 東醫精神醫學 黃義完(外)
  8. 成人病${\cdot}$老人醫學 서순규
  9. 神經精神科學 大韓神經精神醫學會
  10. J Neurogenet. v.12 no.1 Somatic mutation analysis of the APP and Presenilin 1 and 2 genes in Alzheimer's disease brain Reznik-Wolf H;Machado J;Haroutuian V;DeMacro L;Walter GF;Goldman B;Davidson M;Johnston JA;Lannfelt L;Dani SU;Friedman E.
  11. Nat Genet. v.11 no.2 The structure of the presenilin 1(SI82) gene and identification of six novel mutation in early onset AD families Alzheimer's disease collaborative group
  12. Brain Res. v.593 no.2 Senile plaques in cerebral amyloid angiopathy show accumulation of amyloid precursor protein without cytoskeletal abnormalities Tabaton M;Cammarata S;Mandybur T;Richy P;Kawai M;Perry G;Gambetti P.
  13. 張氏景岳全書 張介賓
  14. 辨證奇門全書 錢鏡湖
  15. 醫宗必讀 李仲梓
  16. 備急千金要方(卷四十) 孫思邈
  17. 東醫寶鑑 許浚
  18. 國譯石室秘錄 洪元植(譯)
  19. 古今圖書集成醫部全錄(第7冊) 陳羅雷 등
  20. 中華明醫方劑大全 彭懷仁
  21. 圓光大學校 大學院 碩士論文 天門冬에 의한 腦神經膠細胞로부터 炎症性 細胞活性物質 分泌의 抑制 效果 姜亨沅
  22. 圓光大學校 大學院 博士論文 聰明湯이 老化白鼠 腦組織의 生化學的 變化와 神經細胞의 損傷에 미치는 영향 徐敏華(외)
  23. 東醫神經精神科學會誌 v.9 no.2 加味歸脾聰明湯이 老化白鼠의 血液變化 및 血淸과 腦組織의 抗酸化物 活性에 미치는 影響 김인재(외)
  24. 최신임상정신의학 이근후
  25. 黃帝內經解釋(素問) 楊維傑(編)
  26. 黃帝內經解釋(靈樞) 楊維傑(編)
  27. 大韓韓醫學會誌 v.16 no.1 腦의 機能에 대한 臟象論的 考察 成彊慶
  28. 東醫生理學 金完熙(외 編著)
  29. 本草綱目 李時珍
  30. 醫林改錯 王淸任
  31. 湖北中醫雜誌 v.18 no.124 益氣聰明湯治療腦血管神經性病變的體會 王乃石
  32. 心-腦-神志病辨證論治 張明准(외)
  33. 實用中醫內科學 黃大東(외)
  34. 原色臨床本草學 辛民敎
  35. 漢藥臨床應用 李商仁(외)
  36. Genes Dev. v.13 Bcl-2 family members and the mitochondria in apoptosis Gross, A.;McDonnell, J.M.;Korsmeyer, S.J.
  37. Nat Cell Biol. v.1 Bcl-2 proteins: inhibitors of apoptosis or regulators of mitochondrial homeostasis? Vander Heiden, M.G.;Thompson, C.B.
  38. Proteomics v.1 no.6 Analysis by matrix assisted laser desorption/ionisation-time of flight mass spectrometry of the post-translational modifications of alpha 1- antitrypsin isoforms separated by two-dimensional polyacrylamide gel electrophoresis Mills PB;Mills K;Johnson AW;Clayton PT;Winches
  39. Proteomics v.1 no.10 New approaches to proteomic analysis of breast cancer Wulfkuhle JD;McLean KC;Paweletz CP;Sgroi DC;Trock BJ;Steeg PS;Petricoin EF 3rd.
  40. Electrophoresis v.21 Proteomics to display lovastatin-induced protein and pathway regulation in rat liver Sandra S;Cristine L. G;John JL;Andrew ML;Angel MA;Anthony JM;Maria CR;Anderson NL