Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects of Guisinhwan on the Ovariectomized Rat Model of Postmenopausal Osteoporosis

귀신환이 난소적출 백서의 골다공증에 미치는 영향

  • Kim Tae Hee (Department of Gynecology, College of Oriental Medicine, Wonkwang University) ;
  • Kang Young Keum (Department of Gynecology, College of Oriental Medicine, Wonkwang University) ;
  • Ahn Kyu Hwan (Department of Gynecology, College of Oriental Medicine, Wonkwang University) ;
  • Kim Song Baeg (Department of Gynecology, College of Oriental Medicine, Wonkwang University) ;
  • Cho Han Baek (Department of Gynecology, College of Oriental Medicine, Wonkwang University) ;
  • Yoo Sim Keun (Department of Gynecology, College of Oriental Medicine, Wonkwang University)
  • 김태희 (원광대학교 한의과대학 부인과학교실) ;
  • 강영금 (원광대학교 한의과대학 부인과학교실) ;
  • 안규환 (원광대학교 한의과대학 부인과학교실) ;
  • 김송백 (원광대학교 한의과대학 부인과학교실) ;
  • 조한백 (원광대학교 한의과대학 부인과학교실) ;
  • 유심근 (원광대학교 한의과대학 부인과학교실)
  • Published : 2004.10.01
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Abstract

Aging is characterized by an age-dependent reduction in bone density. Pronounced bone loss by postmenopausal estrogen deficiency induces a bad effect on dynamic balance of bone metabolism. When the bone density is reduced to the level below the fracture threshold, the risk for fracture is greatly increased. The purpose of this study is to examine what are the effects of the Guisinhwan(GSH : 歸腎丸) on the ovariectomized rat model of postmenopausal osteoporosis. The results of the experiment are as follows: Body weight in control group showed significant increase in comparison with sham, but that in GSH-treated showed no change in comparison with control. The level of serum albumin in control group showed significant decrease in comparison with sham. That in GSH-treated was slightly decreased in comparison with control. The level of serum ALP activity in control group showed significant increase in comparison with sham, but that in GSH-treated was significantly decreased in comparison with control. The level of serum phosphorous, calcium, GOT, GPT, T3 did not significant change among the three groups. The level of serum estrogen in control group showed slightly decreased in comparison with sham, but that in GSH-treated showed no change in comparison with control. The level of serum T4 in control group showed significant increase in comparison with sham, but that in GSH-treated was significantly decreased in comparison with control. Trabecular bone area as well as trabecular thickness in control group showed significant decrease In comparison with sham. Those in GSH-treated showed significant increase in comparison with control. Trabecular number did not significant change among the three groups. Trabecular separation only in GSH-treated showed significant decrease in comparison with control. Osteoclast number in control group showed significant increase in comparison with sham. That in GSH-treated showed significant decrease in comparison with control. Oseoblast surface in control group showed significant increase in comparison with sham, but that in GSH-treated showed no change in comparison with control. According to the above these results, GSH has shown to be capable of preventing and curing osteoporosis caused by old-aged and postmenopause.

Keywords

References

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