Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Study on Anti-thrombotic Activity, Superoxide Generation in Human Neutrophils and Platelet Aggregation in Human Blood of Hwao-tang

  • Park Won Hwan (Department of Diagnostics, College of Oriental Medicine, Deongguk University) ;
  • Park Soo Young (Department of Diagnostics, College of Oriental Medicine, Deongguk University) ;
  • Park Tae Woo (Department of Diagnostics, College of Oriental Medicine, Deongguk University) ;
  • Kim Jong Gu (Department of Diagnostics, College of Oriental Medicine, Deongguk University) ;
  • Kim Seog Ha (Department of Diagnostics, College of Oriental Medicine, Deongguk University) ;
  • Kim Cherl Ho (Department of Biochemistry, College of Oriental Medicine, Dongguk University)
  • Published : 2004.10.01
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Abstract

The present paper reports the effects of Hwaotang an atherosclerosis using a spontaneous experimental model, We have also investigated the pharmacological effect of Hwaotang on collagen- and ADP-induced blood platelet aggregation, thrombin-induced conversion of fibrinogen and fibrinolysis in in vitro experiments, and various effects on stimuli-induced superoxide generation in human neutrophils. Hwao-tang was shown to have inhibitory effect on collagen- and ADP-induced blood platelet aggregation, on thrombin-induced conversion of fibrinogen to fibrin and on the activity of plasminogen or plasmin. Hwao-tang also significantly inhibited fMLP-induced superoxide generation in a concentration-dependent manner, but not that induced by arachidonic acid. Hwao-tang inhibited neutrophil functions, including degranulation, superoxide generation, and leukotriene B4 production, without any effect on 5-lipoxygenase activity. In conclusion, the protection of extracts of Hwao-tang on the ischemic infarction induced artificially might be involved to their inhibition of thrombotic action. The results also indicate that Hwao-tang exerts the effects on superoxide generation related to the inhibition of neutrophil functions.

Keywords

References

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