Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effect of Kamichungbieum on the Isolated Rat Aorta

가미청비음이 흰쥐의 적출 동맥에 미치는 영향

  • Published : 2004.08.01
Download PDF
⟨ Previous Next ⟩

Abstract

The purpose of this research was to investigate the effects of supercritical fluid extract of Kamichungbieum (SFE) on the contraction of isolated rat aorta. The contractile force of rat aorta was measured with force displacement transducer under 1.5g loading tension. The contraction of aorta induced by phenylephrine 0.1 μM was inhibited by SFE. The aorta relaxed by SFE was inhibited by the pretreatment of L-NNA, ODQ or indomethacin, respectively. These results indicate that SFE induce the relaxation of isolated aorta via activation of nitric oxide, cAMP and cyclooxygenase in epithelium cells.

Keywords

References

  1. 東醫眼耳卑咽喉科學(增補版) 蔡炳允
  2. Dense Gases for Extraction and Refining Leiner, S.;Stahl, E.;Quirin, K.W.;Gerald, D.(Eds.)
  3. Kor. J. Oriental Physiology & Pathology v.18 no.2 Effect of Kamichungbieum on allergy reaction Kim, K.S.;Lee, D.H.;Kwon, Y.A.;Choi, S.Y.;Eun, J.S.
  4. Kor. J. Oriental Physiology & Pathology v.17 no.5 Effect of Fructus Rubi on the isolated rat aorta Sun, S.G.;Oh, K.S.;Kim, N.S.;So, E.H.;Han, J.H.
  5. FASEB J. v.3 no.1 Endothelium-derived nitric oxide: action and properties Ignarro, L.J.
  6. Pharmacology Rang, H.P.;Dale, M.M.;Ritter, J.M.
  7. Eur. J. Pharm. v.274 Endothelium-dependent relaxation resistant to NG-nitro-L-arginine in rat aorta Hadake, K.;Wakabayashi, I.;Hishda, S.
  8. Cicr. Res. v.83 A major role for prostacyclin in nitric oxide-induced occular vasorelaxation in the piglet Hardy, P.;Abran, D.;Hou, X.;Lahaie, I.;Peri, K.G.;Asselin, P.;Varma, D.R.;Chemtob, D.R.
  9. 이우주의 약리학 강의(제4판) 김경환
  10. Indian J. Med. Res. v.119 Mechanism of action of the cisapride-induced vasodilatation in renal vasculature of rat Tekes, E.;Bayar, B.;Emre-Aydingoz, S.;Tuncer, M.
  11. Brain Res. v.641 no.2 Comparison of the effects of NG-nitro-L-arginine and indomethacin on the hypercapnic cerebral blood flow increase in rats Wang, Q.;Pelligrino, D.A.;Paulson, O.B.;Lassen, N.A.
  12. J. Physiol Pharmacol. v.55 no.1 Platelet-activating factor mediates Porphyromonas gingivalis lipopolysaccharide interference with salivary mucin synthesis via phosphatidylinositol 3-kinase-dependent constitutive nitric-oxide synthase activation Slomiany, B.L.;Slomiany, A.
  13. 생리학(제6판) 성호경
  14. FASEB J. v.6 Nitric oxide as a secretory product of mammalian cells Nathan, C.
  15. Nature v.336 Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the Brain Garthwaite, J.;Charles, S.L.;Chess-Williams, R.
  16. Boichem Biophysic Res Commum. v.157 Nitric oxide ; A cytotoxic and activated macrophage effector molecule Hibbs, J.B.;Taintor, R.R.;Vavrin, Z.;Rachlin, E.M.
  17. FASEB J. v.7 Niric oxide sythesis inhibition induced leukocyte adhesion via superoxide and master cell Kubes, P.;Kanwar, S.;Niu, X.;Gaboury, J.P.
  18. Nature v.327 Nitric oxide release accounts for the biology activity of endothelium derived relaxing factor Palmer, P.M.J.;Ferrige, A.G.;Monacada, S.
  19. Nature v.349 Endogenous nitric oxide release required for long term synatic depression in the cerebellum Shibuki, K.;Okada, D.
  20. J. Exp. Med. v.169 Nitric oxide macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells Stuehr, D.J.;Nathan, C.F.