Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects on Testosterone of Splague-Dawley by Methoxychlor

Methoxychlor 투여한 흰쥐에 있어서의 Testosterone의 변화

  • Baek Byeong Kirl (Biosafety Research Institute, Chonbuk National University) ;
  • Lee Bou Oung (Biosafety Research Institute, Chonbuk National University) ;
  • Lim Chae Woong (Biosafety Research Institute, Chonbuk National University) ;
  • Kwon Hyuk Nyun (Biosafety Research Institute, Chonbuk National University) ;
  • Hur Jin (Biosafety Research Institute, Chonbuk National University) ;
  • Lee Eun Yong (Biosafety Research Institute, Chonbuk National University) ;
  • Lee Hee Kwon (Korean Raspberry Experiment Station, Gochang-Gun Agriculture Development & Technology Center) ;
  • Lee Sung Ill (Sohae College) ;
  • Kim Byung Su (Toyama Medical and Pharmaceutical University) ;
  • Lee Hyoung Ja (Korea Advanced Food Research Institute) ;
  • Jeon Byung Hun (College of Oriental Medicine, Won-Kwang University)
  • 백병걸 (전북대학교 생체안전성연구소) ;
  • 이부웅 (전북대학교 생체안전성연구소) ;
  • 임채웅 (전북대학교 생체안전성연구소) ;
  • 권혁년 (전북대학교 생체안전성연구소) ;
  • 허진 (전북대학교 생체안전성연구소) ;
  • 이은영 (전북대학교 생체안전성연구소) ;
  • 이희권 (고창군 복분자 연구소) ;
  • 이성일 (서해대학교) ;
  • 김병수 ;
  • 이형자 (한국식품공업협회 부설 한국식품연구소) ;
  • 전병훈 (원광대학교 한의과대학)
  • Published : 2004.08.01
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Abstract

In order to establish the experimental clinical model for evaluating the influences on the sexual hormones of SD-rat administrated with Methoxychlor(MET), it was dissolved in acetone and olive oil (1:19), which was administrated orally at doses of 200㎎/㎏ body weight/day for 7 days. The Testosterone value was measured in sera by Gamma Count with 1251 isotype, also weights of the body, testis and liver were measured for 15 weeks. Testosterone in the serum of intacted SD-rats was 0.51±0.43ng/㎖(n=5), but it was 0.69±0.18(n=2)ng/㎖l on 1 week. 0.28±0.05ng/㎖(n=2) on 3 week, 1.52±0.95ng/㎖(n=3) on 5 week, and 0.54±1.95 ng/㎖(n=3) 15 week post-dosing MET, respectively. Histologically, the numbers of spermatozoa and Leydig cells were reduced, which might influence to reduce sexual hormone, and AST and ALT was not increased in the serum due to administrating with MET, blood profile was not changed according to the administration of MET excepting MCH(Mean Corpuscular Hemoglobin). This study suggest that change of male sexual hormone by MET be a experimental model for evaluating some drugs associate with sex hormone.

Keywords

References

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