Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Cytotoxic Activity of 13(E)-Labd-13-ene-8$\alpha$, 15-diol

  • Lim Jin A (Department of Herbal Resources, Professional Graduate School of Oriental Medicine and Institute of Basic Natural Science) ;
  • Kwang Jung Sook (Department of Dental Hygiene, Mokpo Science College) ;
  • Yu Byung Soo (Division of Bionano Chemistry, Wonkwang University) ;
  • Baek Seung Hwa (Department of Herbal Resources, Professional Graduate School of Oriental Medicine and Institute of Basic Natural Science)
  • Published : 2004.08.01
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Abstract

The cytotoxic activity of 13(E)-labd-13-ene-8α, 15-diol (1) was evaluated against tumor cell lines. A comparison of IC/sub 50/ values of this compound in cancer cell lines showed that their susceptibility to this compound decreased in the following order: P388>B16{F10>MDA-MB-231>A549>KB>SNU-C4 by the MTT method. 13(E}-Labd-13-ene-8α, 15-diol (1) was the most effective growth inhibitor of P388 murine leukaemia cell lines, producing approximately 8.3㎍/mL of IC/sub 50/ in the MTT method.

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References

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