Nutrition Contents and Health Status, Blood Glucose Response Effect for NIDDM Patients of Inonotus Obliquus in Culturing Method by Using Unpolished Rice

현미에서 배양된 차가버섯 분말의 영양성분과 제2형 당뇨환자의 건강지표 및 혈당관련인자에 미치는 영향

  • Kim, Won-Jong (Ye-Nong Mushroom Research Center) ;
  • Koo, Jae-Geun (Faculty of Applied Ocean Science and Technology, Kunsan National University) ;
  • Lee, Tae-Hun (R & D Center, Dongwon F & B Co.) ;
  • Han, Jong-Hyun (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Park, Sung-Hye (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 김원종 (예농버섯연구소) ;
  • 구재근 (군산대학교 해양응용공학부 식품공학) ;
  • 이태헌 (동원 F & B (주)식품연구소) ;
  • 한종현 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 박성혜 (원광대학교 한의학전문대학원 한약자원개발학과)
  • Published : 2005.02.25

Abstract

The purpose of this study was to investigate the possibility of Inonotus obliquus as an functional resource. To assess the effects of Inonotus obliquus in culturing method by using unpolished rice in 15non-insulin dependent diabetes mellitus persons, we examined changes of hematological and chemical variables, DM indices content in serum during the Inonotus obliquus supplementation. GOT, GPT concentrations were significantly decreased. But TIBC content was significantly increased. Fasting glucose level during Inonotus obliquus supplementation was decreased respectively. These results show that modest dose of Inonotus obliquus in culturing method by using unpolished rice supplementation can decrease fasting blood glucose level without any changes in health indices and nutrition status of the non-insulin dependent diabetes mellitus person. These results indicated that Inonotus obliquus in culturing method by using unpolished rice diet is effective therapeutic regimen for the control of metabolic derangements in diabetes mellitus. Also, the results imply that Inonotus obliquus in culturing method by using unpolished rice can be used as possible functional food materials. However, large amounts of Inonotus obliquus in culturing method by using unpolished rice showed be used cautiously application.

Keywords

References

  1. Han HK, Lim SJ. Effect of fractions from methanol extract of Commelina ommuris on blood glucose level and energy metabolism in streptozotocin-induced diabetic rats. Korean J Soc Food Sci 14 : 577-583, 1998.
  2. Hong JS, Kim YH, Lee KR, Kim MK, Cho CI, Park KH, Choi YH, Lee JB. Composition of organic acid, fatty acid in Pleurotus ostreatus, Lentinus edodes and Agaricus bisporus. Korean J Food Sci Technol 20 : 100-106, 1988.
  3. Lee GD, Chang HG, Kim HK. Antioxidative and nitrite-scavenging activities of edible mushrooms. Korean J Food Sci Technol 29 : 432-436, 1997.
  4. Rosanne SL. Nutrition education in the clinical setting for medical residents. J Am Diet Assoc 91 : 223-227, 1991.
  5. 이종호. 당뇨병의 식사요법. 대한영양사회 임상교육과정 2 : 21, 1995.
  6. Choi JS, Chung HY, Han SY. A preliminary study on hypocholesterolemic and hypoglycemic activities of some medical plants. Korean J Pharm 21 : 153-157, 1990.
  7. Kim TH, Yang KS, Whang SH. Studies on the physiochemical activities of Commelinae herba extract on the normal and the streptozotocin-induced hyperglycemic rats. Thesis collection, SM Pharm SCI 7 : 39-59, 1990.
  8. Bailery CJ, Day C. Traditional plant medicines as treatments for diabetes. Diabetes Care 12 : 553-564, 1989. https://doi.org/10.2337/diacare.12.8.553
  9. Hong JS, Kim YH, Kim MK, Kim TY, Kim KJ. Studies on the lipids composition of Korean edible mushrooms. J Korean Soc Dietary Culture 5 : 437-443, 1990.
  10. Rajarathnam S, Bang Z. Pleurotus mushrooms as a nutritional food. In tropical mushrooms. Chang ST, Quimio TH. The Chinese University Press, Hong Kong. pp.363-380, 1982.
  11. Cho YJ, Kim HA, Bang MA, Kim EH. Effects of dietary mushroom on blood glucose levels, lipid concentration and glutathione enzymes in streptozotocin-induced diabetic rats. Korean J Nutrition 35(2) : 183-191, 2002.
  12. Kim MW, Park MH, Kim GH. Effects of mushroom protein-bound polysaccharides ion blood glucose levels and energy metabolism in streptozotocin-induced diabetic rats. Korean J Nutr 30(7): 743-750, 1997.
  13. Kim YS, Park SW, Kim SJ, Park SJ, Ryu CH, Choi HJ, Kim JO, Kim DK, Ha YL. Preparation of mushroom mycelia-cultured traditional Meju with enhanced anticarcinogenicity and sensory quality. J Korean Soc Food Sci Nutr 31(6): 986-993, 2002. https://doi.org/10.3746/jkfn.2002.31.6.986
  14. Bulatov PK, Berezima MP, Jakimov PA. Tsaga ii ee letsebnoje primenie pri rake IV. Stadii, Leningarad. p.326, 1959.
  15. Shivrina AN. Chemical characteristics of compounds extracted from Inonotus obliquus. Chem Abstr 55 : 17271-17279, 1967.
  16. Kier L. Triterpenes of Poria obliqua. J Pharm Sci 50 : 471-474, 1961. https://doi.org/10.1002/jps.2600500605
  17. Kahlos K, Hiltunen R. Indentification of some lanostane type triterpenes from Inonotus obliquus. Acta Pharm Fenn 92 : 220-224. 1983.
  18. Ludwiczak RS and Wrzeciono U. Forschungen uber die chemischen bestandteil de Inonotus obliquus IV. Ergosterol Rocz Chem 34 : 1701-1705, 1975.
  19. Loviagina EV, Shivrina AN. On steroid compound of the Chaga fungus. Biobimija 27 : 794-800.
  20. Ichimura T, Watanave O, Maruyama S. Inhibition of HIV-1 protease by water soluble lignin-bike substance from an edible mushroom, Fuscoporia obliqua. Biosci Biothechnol Biochem 62 : 575-577.
  21. Mizuno T, Zhuang C, Abe K, Okamoto H, Kiho T, Ukai S, Ieclerc S, Meijer L. Antitumor and hypoglycemic activities of polysaccharides from the Sclerotia and Mycelia of Inonotus obliquus. Int J Med Mushrooms 1 : 301-316, 1999. https://doi.org/10.1615/IntJMedMushr.v1.i4.20
  22. 한국공업협회. 식품공전. 문영사, 서울. pp.541-581, 2002.
  23. Hwang JB, Yang MO, Shin HK. Survey for amino acid of medicinal herb. Korean J Food Sci Technol 30: 35-41, 1998.
  24. 이세열, 정윤섭. 임상병리검사법. 연세대학교출판부,서울. pp.59-67, 1993.
  25. Park SH, Baek SH, Han JH. The influences of Meles meles oil on health status, diabetic index and serum lipid profile in non-insulin dependent diabetes melitus patients. J Korean Soc Food Sci Nutr 33(7): 1139-1146, 2004. https://doi.org/10.3746/jkfn.2004.33.7.1139
  26. Baker JR, Metalf PA, Holdaway IM, Johnson RN. Serum fructosamine concentration as measure of blood glucose control type I diabetes mellitus. Br Med J 290: 352-356, 1985. https://doi.org/10.1136/bmj.290.6465.352
  27. Lloyd D, Marples J. Simple colorimetry of glycated serum protein in a contrifugal analyzer. Clin Chem 30:1688-1702, 1984.
  28. Park HR. Frequency of chronic diabetic complication, indices of glucose control and serum fructosamine in non-insulin dependent diabetic. Diabetes 12 : 45-50, 1987.
  29. Wee SO, Kim DM, Sung SK, Yoo HJ. Serum c-peptide concentration as an index of insulin treatment in NIDDM patients. Diabetes 11: 57-61, 1986.