Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Isolation of Angiotensin Converting Enzyme Inhibitory Component from the Seeds of Xanthium strumarium

창이자(蒼耳子)로부터 안지오텐신 전환효소 억제 유효 성분의 분리

  • Lee, Yun-Mi (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kang, Dae-Gill (Professional Graduate School of Oriental Medicine, Medicinal Resources Research Institute (MeRRI), Wonkwang University) ;
  • Kim, Myung-Gyu (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Jang, Ji-Yeon (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Ho-Sub (Professional Graduate School of Oriental Medicine, Medicinal Resources Research Institute (MeRRI), Wonkwang University)
  • 이윤미 (원광대학교 한의학전문대학원) ;
  • 강대길 (원광대학교 한의학전문대학원, 의약자원연구센터) ;
  • 김명규 (원광대학교 한의학전문대학원) ;
  • 장지연 (원광대학교 한의학전문대학원) ;
  • 이호섭 (원광대학교 한의학전문대학원, 의약자원연구센터)
  • Published : 2005.02.25
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Abstract

In the courses of in vitro screening for the angiotensin converting enzyme (ACE) inhibitory activity of the various extracts from medicinal plants, n-BuOH soluble extract of the seeds of Xanthium strumarium was found to exhibit distinctive angiotensin converting enzyme (ACE) inhibitory activity. Bioassay-guided fractionation and purification of the n-BuOH soluble extract of the seeds of Xanthium strumarium afforded a new $xanthiazone-11-{\beta}-glucopyranoside$. The ACE activity was significantly inhibited by the addition of a new $xanthiazone-11-{\beta}-glucopyranosidein$ a dose-dependent manner of which $IC_{50}$ value was $21.8\;{\mu}g/ml$.

Keywords

References

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