Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Inhibitory Effect of Saururus chinensis (Lour.) Baill Extracts on Allergy in Mouse Models

Mouse 모델 알레르기 반응에서 삼백초(三白草)가 미치는 영향

  • Suk, Min-Hee (Department of Physiology.Biomedical Research Center of Oriental Medicine, Dong-Eui University) ;
  • Kang, Kyung-Hwa (Department of Physiology.Biomedical Research Center of Oriental Medicine, Dong-Eui University) ;
  • Choi, Yung-Hyun (Department of Biochemistry, College of Oriental Medicine, Dong-Eui University) ;
  • Choi, Byung-Tae (Department of Anatomy, College of Oriental Medicine, Dong-Eui University) ;
  • Lee, Yong-Tae (Department of Physiology.Biomedical Research Center of Oriental Medicine, Dong-Eui University)
  • 석민희 (동의대학교 한의과대학 생리학교실.한방바이오연구센터) ;
  • 강경화 (동의대학교 한의과대학 생리학교실.한방바이오연구센터) ;
  • 최영현 (동의대학교 한의과대학 생화학교실) ;
  • 최병태 (동의대학교 한의과대학 해부학교실) ;
  • 이용태 (동의대학교 한의과대학 생리학교실.한방바이오연구센터)
  • Published : 2005.02.25
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Abstract

We investigated the effect of Saururus chinensis (Lour.) Baill (SCB) on allergy in mice. We conformed compound 48/80-induced mesenteric mast cell degranulation, active systemic anaphylatic shock and histamine release. Also observed acetic acid-induced vascular permeability and anti-dinitrophenyl (DNP) IgE-mediated passive cutaneous anaphylaxis. SCB inhibited mesenteric mast cell degranulation and active systemic anaphylatic shock induced by compound 48/80 dose-dependently. When SCB was pretreated by intra-peritoneal injection, the plasma histamine levels were reduced. SCB also significantly inhibited acetic acid-induced vascular permeability and anti-DNP IgE-mediated passive cutaneous anaphylaxis. In addition, SCB reduced IL-10 mRNA expression of the lung on ovalbumin-induced allergy. These results indicate that SCB inhibits allergy.

Keywords

References

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