Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Antimalarial Activity and Cytotoxicity of Herb-medicine Against P. falciparum in vitro

전통적으로 말라리아 처방에 다용되는 한약재에 대한 항 말라리아 효능과 세포독서에 대한 연구

  • Kim, Youn-Chul (College of Pharmacy, Wonkwang University) ;
  • Kim, Jong-Ho (Department of Infection Biology, College of Medicine, Wonkwang University) ;
  • Park, Hyun (Department of Infection Biology, College of Medicine, Wonkwang University) ;
  • Kim, Yong-Man (Department of Infection Biology, College of Medicine, Wonkwang University) ;
  • Kim, Min-Kyeoung (Department of Infection Biology, College of Medicine, Wonkwang University) ;
  • Jeon, Byung-Hun (Department of Pathology, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Hye-Sook (Faculty of Pharmaceutical Siences, Okayama University) ;
  • Yun, Ki-Jung (Department of Pathology, College of Medicine, Wonkwang University)
  • 김윤철 (원광대학교 약학대학) ;
  • 김종호 (원광대학교 의과대학 감염생물학교실) ;
  • 박현 (원광대학교 의과대학 감염생물학교실) ;
  • 김용만 (원광대학교 의과대학 감염생물학교실) ;
  • 김민경 (원광대학교 의과대학 감염생물학교실) ;
  • 전병훈 (원광대학교 한의과대학 병리학 교실) ;
  • 김혜숙 (오까야마대학교 약학대학 의약품 정보학교실) ;
  • 윤기중 (원광대학교 의과대학 병리학교실)
  • Published : 2005.02.25
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Abstract

Eighteen methanol extracts of herb-medicine used for malarial and antipyretic therapies in Korea were assessed for their antimalarial activities. Eighteen extracts showed evident antimalarial activity with $EC_50$ values ranged from $2.8\;to\;110mg/m{\ell}$. Evodia fructus showed the antimalarial activity of $EC_50\;=\;4.1\;mg/m{\ell}$ and higher selective toxicity(>8) with no cytotocixity for mammalian cells. This indicated that Evodia fructus is potent for a new effective and safe antimalarial agent. The methanol extract of Physalli radix had also strongest antiplasmodial activity with $EC_50$ value of $2.8{\mu}g/m{\ell}$.

Keywords

References

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