Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Morphological Studies on Hair Growth Effect of Samultang-gamibang

사물탕가미방(四物湯加味方)이 원형탈모 생쥐의 발모효과에 관한 형태학적 연구

  • Kwon, Gang-Joo (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Chang-Hyun (Department of Anatomy, College of Oriental Medicine, Woosuk University) ;
  • Lee, Moon-Won (Department of Anatomy, College of Oriental Medicine, Woosuk University) ;
  • Mun, Yeun-Ja (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Choi, Doo-Ho (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Hak-Jae (Department of Prescriptionology, College of Oriental Medicine, Sangji University) ;
  • Kim, Ho-Min (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Woo, Won-Hong (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 권강주 (원광대학교 한의학전문대학원) ;
  • 이창현 (우석대학교 한의과대학 해부학교실) ;
  • 이문원 (우석대학교 한의과대학 해부학교실) ;
  • 문연자 (원광대학교 한의학전문대학원) ;
  • 최두호 (원광대학교 한의학전문대학원) ;
  • 이학재 (상지대학교 한의과대학 방제학교실) ;
  • 김호민 (원광대학교 한의학전문대학원) ;
  • 우원홍 (원광대학교 한의학전문대학원)
  • Published : 2005.06.25
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Abstract

This experiment examined the effect of Samultang-gamibang (SGB) on hair growth in spontaneous alopecia areata C57BL/6N mice. We first investigated hair growth effect of SGB compare to control groups after apply to oral administration for 10 weeks and regional treatment in skin for last 4 weeks. We second investigated the number of hair follicle and mast cells after treatment of SGB in spontaneous alopecia areata C57BL/6N mice for 10 weeks. We third investigated immunoreactive density of neuropeptides in skin of spontaneous alopecia areata C57BL/6N mice by immunohistochemical methods. The results were as follows : Hair growing effect of experimental group was observed from 7 weeks after administration of SGB (87.5%). In experimental group, the number of mast cells and eosinophils was significantly decreased compare to control group. Immunoreactive density of substance P and corticotropin releasing factor (CRF) in skin of experimental group was weakly stained in epidermis and subcutaneous tissue compare to control group. Immunoreactive density of CRF-receptor (CRF-R), CRF-binding protein (CRF-BP) in skin of experimental group was increased in epidermis, sebaceous gland, inner root sheath, outer root sheath and secondary hair germ epithelium compare to control group. These results suggest that SGB may be used in treatment of alopecia areata.

Keywords

References

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