Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effect of Acupuncture(PC6) on Behavior, Dopamine Release in the Nucleus Accumbens in Rats Sensitized to Morphine

몰핀에 민감화된 흰쥐의 내관부위 자침이 행동과 측핵의 도파민 유리에 미치는 효과

  • Kim, Sang-Ho (Department of Oriental Neuropsychiatry Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Lyu, Seung-Jun (Department of Oriental Neuropsychiatry Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Tae-Heon (Department of Oriental Neuropsychiatry Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Kang, Hyung-Won (Department of Oriental Neuropsychiatry Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Lyu, Yeoung-Su (Department of Oriental Neuropsychiatry Medicine, College of Oriental Medicine, Wonkwang University)
  • 김상호 (원광대학교 한의과대학 한방신경정신과학교실) ;
  • 류승준 (원광대학교 한의과대학 한방신경정신과학교실) ;
  • 김태헌 (원광대학교 한의과대학 한방신경정신과학교실) ;
  • 강형원 (원광대학교 한의과대학 한방신경정신과학교실) ;
  • 류영수 (원광대학교 한의과대학 한방신경정신과학교실)
  • Published : 2005.08.01
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Abstract

Acupuncture as a therapeutic intervention is widely used for the treatment of many functional disorders such as substance abuse and mental dysfunction. Clinical trials are currently underway to determine the effectiveness of acupuncture in the treatment of drug addiction. Yet, there are still many unanswered questions about the basic mechanism of acupuncture. Studies have shown that both the psychomotor stimulant effects and rewarding properties of addictive drugs, including morphine, are sensitized by repeated drug administration and raised the possibility that both of these effects may De linked to the same or closely overlapping the mesolimbic dopamine systems. Neiguan (PC6) point on the pericardium channel which is associated with the brain and its mental function, has been used to treat mental, psychosomatic disorders and gastroenterological disorders. The present study was designed to investigate the effect of acupuncture on repeated morphine-induced changes in extracellular dopamine levels using in vivo microdialysis and to measure the effect of acupuncture on repeated morphine-induced behavioral changes. Male Sprague-Dawley rats were treated twice a day for three days with increasing doses of morphine (10, 20 and 40 mg/kg, s.c.) or with saline. After 15 days of withdrawal, rats were challenged with morphine hydrochloride (5 mg/kg, s.c.). Acupuncture was applied at bilateral Neiguan (PC6) points for 1min after the morphine challenge. Results showed that acupuncture at the specific acupoint PC6, but not at control points (tail and HE8) significantly decreased both dopamine release, behavior induced by a systemic morphine challenge or a single s.c. morphine injection in the morphine-repeated animals. These results suggest that reduction in sensitization may be one mechanism whereby acupuncture alleviates morphine craving in addicts. Moreover, in a more general sense these results suggest that acupuncture can be used as a therapeutic intervention for correcting reversible malfunction of the body by direction of brain pathway and thus acupuncture can contribute to the biochemical balance in the central nervous system by regulating neurotransmitters.

Keywords

References

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