Applied Chemistry for Engineering (공업화학)

The Korean Society of Industrial and Engineering Chemistry (한국공업화학회)
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Drug Delivery Effect Using Biopolymer Chitosan Nanoparticles

생명고분자 키토산의 나노입자를 이용한 약물전달 효과

  • Lee, Do Hun (Department of Chemical & Bio Engineering, Kyungwon University) ;
  • Lee, Sang-wha (Department of Chemical & Bio Engineering, Kyungwon University) ;
  • Yoo, In Sang (Department of Chemical & Bio Engineering, Kyungwon University) ;
  • Park, Kwon-pil (Department of Chemical Engineering, Sunchon National University) ;
  • Kang, Ik Joong (Department of Chemical & Bio Engineering, Kyungwon University)
  • 이도헌 (경원대학교 화학생명공학과) ;
  • 이상화 (경원대학교 화학생명공학과) ;
  • 유인상 (경원대학교 화학생명공학과) ;
  • 박권필 (순천대학교 화학공학과) ;
  • 강익중 (경원대학교 화학생명공학과)
  • Received : 2005.07.06
  • Accepted : 2005.10.19
  • Published : 2005.12.10
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Abstract

Recently, the interest in the extension of human life and personal health has been increased. Accordingly, many researchers in a pharmacy and a medical world have been making efforts to improve the sustained drug release property and the stability of drug release property in a body. Many biological researches have demonstrated that chitosan derivatives are effective, safe absorption enhancers that can improve the delivery efficiency of drug and vaccine, and they are suitable for controlled drug release because they have good stability, bio-compatibility, and biodegradability. In this study the experiment was performed in vivo by utilizing chitosan nanoparticles as a biopolymer to control drug delivery rate at an optimal temperature, pH, and concentration. It was observed that nanoparticles containing insulin could effectively control the blood glucose at a low level.

최근 인간의 생명 연장과 건강 등에 관심이 많아지면서 약학 및 의학계는 생체 내에서 보다 안정적이며 효과를 나타낼 수 있는 약물 전달 시스템의 개발에 많은 힘을 기울이고 있는 실정이다. 수많은 생화학 연구자들은 키토산이 인체에 거부반응이 없으며 약물과 백신의 전달을 효율적이고 안전하게 흡착능력을 향상시킨다는 것을 밝혀 왔다. 또한 그것은 생분해성, 생체 친화적이라는 장점 때문에 약물 방출 조절에 적당하다고 알려져 있다. 본 연구에서는 생명고분자인 키토산의 나노입자를 제조하여 농도, pH, 최적 온도에서 약물 전달 조절을 in vivo 조건에서 수행하였다. 인슐린을 담지한 키토산 나노입자는 당뇨성 쥐의 혈당을 효과적으로 낮춰 줄 수 있음을 알 수 있었다.

Keywords

Acknowledgement

Supported by : 경기도지역협력연구센터

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