Asian-Australasian Journal of Animal Sciences

  • 제18권11호
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  • Pages.1542-1547
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  • 2005
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  • 1011-2367(pISSN)
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  • 1976-5517(eISSN)
아세아태평양축산학회 (Asian Australasian Association of Animal Production Societies)
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New Evidences of Effect of Melanocortin-4 Receptor and Insulin-like Growth Factor 2 Genes on Fat Deposition and Carcass Traits in Different Pig Populations

  • Chen, J.F. (Agricultural Ministry Key Laboratory of Swine Breeding and Genetics, Huazhong Agricultural University) ;
  • Xiong, Y.Z. (Agricultural Ministry Key Laboratory of Swine Breeding and Genetics, Huazhong Agricultural University) ;
  • Zuo, B. (Agricultural Ministry Key Laboratory of Swine Breeding and Genetics, Huazhong Agricultural University) ;
  • Zheng, R. (Agricultural Ministry Key Laboratory of Swine Breeding and Genetics, Huazhong Agricultural University) ;
  • Li, F.E. (Agricultural Ministry Key Laboratory of Swine Breeding and Genetics, Huazhong Agricultural University) ;
  • Lei, M.G. (Agricultural Ministry Key Laboratory of Swine Breeding and Genetics, Huazhong Agricultural University) ;
  • Li, J.L. (Agricultural Ministry Key Laboratory of Swine Breeding and Genetics, Huazhong Agricultural University) ;
  • Deng, C.Y. (Agricultural Ministry Key Laboratory of Swine Breeding and Genetics, Huazhong Agricultural University) ;
  • Jiang, S.W. (Agricultural Ministry Key Laboratory of Swine Breeding and Genetics, Huazhong Agricultural University)
  • 투고 : 2004.12.21
  • 심사 : 2005.05.15
  • 발행 : 2005.11.01
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초록

The Melanocortin-4 Receptor (MC4R) and Insulin-like Growth Factor 2 (IGF2) are two important candidate genes related to fat deposition and carcass traits. MC4R was found on study on human obesity and then was studied as candidate gene affecting food intake and fat deposition traits in mice and pigs. Insulin-like Growth Factor 2 (IGF2) gene plays an important role on tumor cell proliferation and muscle growth. It also affects fat traits and live weight in pigs. In this paper, MC4R and IGF2 were studied as two candidate genes associated with important economic traits such as fat deposition and carcass traits in five different pig populations. Taq I-PCR-RFLP and Bcn I-PCR-RFLP were respectively used to detect the polymorphism of genotypes of MC4R and IGF2 genes. Different MC4R genotype frequencies were observed in four populations. IGF2 genotype frequencies were also different in two populations. The results of association analysis show both MC4R and IGF2 genes were significantly associated with fat deposition and carcass traits in about 300 pigs. This work will add new evidence of MC4R and IGF2 affecting fat deposition and carcass traits in pigs and show that two genes can be used as important candidate genes for marker assistant selection (MAS) of growth and lean meat percentage in pigs.

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참고문헌

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  2. Postnatal Expression Pattern of Adipose Type Fatty Acid Binding Protein in Different Adipose Tissues of Porcine vol.20, pp.6, 2005, https://doi.org/10.5713/ajas.2007.811
  3. Amplification of the Full-Length PAMP Gene and Difference of the mRNA Expression Among Three Lean Pig Breeds vol.7, pp.12, 2005, https://doi.org/10.1016/s1671-2927(08)60409-5
  4. New Evidence of Alleles (V199I and G52S) at the PRKAG3 (RN) Locus Affecting Pork Meat Quality vol.21, pp.4, 2005, https://doi.org/10.5713/ajas.2008.70373