Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Effects of Licorice on Embryonic and Fetal Development in Rats

감초가 랫드의 배 · 태자 발생에 미치는 영향

  • Shin Sunhee (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University) ;
  • Jang Ja Young (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University) ;
  • Baek In-Jeoung (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University) ;
  • Yon Jung-Min (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University) ;
  • Nam Sang-Yoon (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University) ;
  • Yun Young Won (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University) ;
  • Cho Dae-Hyun (Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Kim Soon-Sun (Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Rhee Gyu-Seek (Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Kwack Seung-Jun (Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Kim Yun-Bae (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University)
  • 신선희 (충북대학교 수의과대학 및 동물의학연구소) ;
  • 장자영 (충북대학교 수의과대학 및 동물의학연구소) ;
  • 백인정 (충북대학교 수의과대학 및 동물의학연구소) ;
  • 연정민 (충북대학교 수의과대학 및 동물의학연구소) ;
  • 남상윤 (충북대학교 수의과대학 및 동물의학연구소) ;
  • 윤영원 (충북대학교 수의과대학 및 동물의학연구소) ;
  • 조대현 (국립독성연구원 생식독성과) ;
  • 김순선 (국립독성연구원 생식독성과) ;
  • 이규식 (국립독성연구원 생식독성과) ;
  • 곽승준 (국립독성연구원 생식독성과) ;
  • 김윤배 (충북대학교 수의과대학 및 동물의학연구소)
  • Published : 2005.12.01
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Abstract

The developmental toxicity of water extract of licorice (Glycyrrhiza glabra) was evaluated in rats. Licorice extract (500, 1,000 or 2,000 mg/kg) was dissolved in drinking water and orally administered to male rats from 9 weeks before mating to the day of copulation, and to females from 2 weeks before mating to gestational day 19. On gestational day 20, the animals were sacrificed for Cesarian section, and maternal and fetal abnormalities were examined. Licorice extract neither induce clinical signs, nor affect the body weight gain, feed and water intake, estrous cycle, copulation and fertility rates, blood $17\beta-estradiol$ level and organ weights of dams. Also, the implantation and development including body weights, absorption and death of embryos and fetuses were not influenced by in utero exposure to licorice. In addition, there were no increases in external, visceral and skeletal abnormalities of fetuses. Taken together, it is suggested that no observed adverse effect level of licorice extract is higher than 2,000 mg/kg, and that long-term in utero exposure to licorice might not cause developmental toxicities of embryos and fetuses.

Keywords

References

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