Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effects of DaeSiHo-Tang extract on Hypertension and Arterial Contraction

대시호탕(大柴胡湯)이 고혈압과 수축혈관에 미치는 영향

  • Yeo Un-Hong (Department of Physiology, College of Oriental Medicine, Semyung University) ;
  • Jo Hak-Jun (Department of Korean Medical Classics, College of Oriental Medicine, Semyung University) ;
  • Kim Ho-Hyun (Department of Physiology, College of Oriental Medicine, Semyung University)
  • 여운홍 (세명대학교 한의과대학 생리학교실) ;
  • 조학준 (세명대학교 한의과대학 원전의사학교실) ;
  • 김호현 (세명대학교 한의과대학 생리학교실)
  • Published : 2005.12.01
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Abstract

This study was undertaken to define the effect of DaeSiHo-Tang extract on the hypertension in spontaneous hypertensive rat and norepinephrine-induced arterial contraction in rabbit. Systolic blood pressure and blood velocity were significantly attenuated by administration of DaeSiHo-Tang extract. but blood flow and renin-angiotensin-aldosterone system unaffected by DaeSiHo-Tang extract. The relaxation effect of DaeSiHo-Tang extract was dependent on the presence of endothelium, showing that DaeSiHo-Tang extract-induced relaxation was not observed in the strips without endothelium. The endothelium-dependent relaxation induced by DaeSiHo-Tang extract was decreased by the pretreatment of $N{\omega}$-nitro-L-arginine or methylene blue, but it was not observed in the strips pretreated with indomethacin or tetraethylammonium chloride. When $Ca^{2+}$ was applied, the strips which were contracted by norepinephrine in a $Ca^{2+}$-free solution, arterial contraction was increased. But pre-treatment of DaeSiHo-Tang extract inhibited contractile response to $Ca^{2+}$. These results indicate that antihypertensive effect of DaeSiHo-Tang extract is due to descend arterial resistance by the arterial relaxation through the formation of nitric oxide in the vascular endothelial cells.

Keywords

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