Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Chrysanthemum morifolium inhibits inflammatory responses in IFN-γ and LPS-induced mouse peritoneal macrophages

  • Na Ho-Jeong (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University) ;
  • Cha Dong-Seok (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University) ;
  • Jeon So-Ra (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University) ;
  • Bu Young-Min (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University) ;
  • Jeong Won-Hwan (Gochang GukHwa festival Committee) ;
  • Jeon Hoon (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University)
  • Published : 2006.09.01
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Abstract

Chrysanthemum morifolium (CM) is a herb widely used in medicine for the treatment of a variety of diseases. In this study, using mouse peritoneal macrophages, we have examined whether CM affects nitric oxide (NO), tumor necrosis factor $(TNF)-\alpha$ and interleukin (IL)-6 induced interferon $(IFN)-\gamma$ and lipopolysaccharide (LPS). CM inhibits $IFN-\gamma$ and LPS-induced NO in dose dependent manner. We also found that CM inhibits pro-inflammatory cytokine, $TNF-\alpha$ and IL-6. The expression of cyclooxygenase-2 was reduced by CM. These finding means that CM can be used in controlling macrophages-mediated inflammatory disease.

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References

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