Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Anti-hyperlipidemic Effects of the Herbal Extract Mixture of Cnidium officinale, Petasites japonicus and Coptis chinensis on Mice with Tyloxapol

천궁(川芎), 머위, 황연(黃連) 추출물 조성이 생쥐의 지질대사에 미치는 영향

  • Kim, Sang-Dae (Department of Physiology, College of oriental Medicine, Dongguk University) ;
  • Ahn, Sang-Hyun (Department of Anatomy, College of oriental Medicine, Dongguk University) ;
  • Kim, Jin-Taek (Department of Anatomy, College of oriental Medicine, Dongguk University) ;
  • Shin, Heung-Mook (Department of Physiology, College of oriental Medicine, Dongguk University)
  • 김상대 (동국대학교 한의과대학 생리학교실) ;
  • 안상현 (동국대학교 한의과대학 해부학교실) ;
  • 김진택 (동국대학교 한의과대학 해부학교실) ;
  • 신흥묵 (동국대학교 한의과대학 생리학교실)
  • Published : 2006.04.25
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Abstract

This study was performed to evaluate the effect of the herbal extract mixture of Cnidium officinale, Petasites japonicus and Coptis chinensis (CPC) on the lipids metabolism in mice with tyloxapol. ICR mice weighing between 30-40 g were divided into four groups: normal group, 600mg/kg tyloxapol injected group, $50\;{\mu}g/g$ CPC treated group 6h after tyloxapol injection (SAM1), and tyloxapol and CPC treated group (SAM2), respectively. Tyloxapol or CPC was injected intraperitoneally. Tyloxapol caused an elevation of total cholesterol (TC), triglycerides(TG), and LDL-cholesterol and a decrease of HDL-cholesterol. In addition, tyloxapol induced accumulation of lipid including cholesterol in both the liver and kidney. Serum levels of TC, TG and LDL-cholesterol were decreased whereas HDL-cholesterol was increased by CPC. CPC increased in HDL-cholesterol /total cholesterol ratio and lowered atherogenic index. The levels of TC, TG and LDL-cholesterol by CPC were rather lower in SAM2 than SAM1. CPC also inhibited lowering HDL-cholesterol by tyloxapol. CPC reduced lipid blots and cholesterol particles in both the deposition and size in the liver and kidney with tyloxapol. These results suggest that CPC might be expected to be beneficial for protection and treatment of hyperlipidemia by the disturbance of lipid metabolism.

Keywords

References

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