Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Evaluation of Korean Phytomedicinal Plants on inhibition of Prostaglandin $E_2\;(PGE_2)$ Production and Cyclooxygenase-2 (COX-2) in LPS-stimulated U937 Cells

LPS로 활성화된 U937세포에서 Prostaglandin $E_2\;(PGE_2)$ 생성 및 Cyclooxygenase-2 (COX-2) 활성 억제에 대한 한약제의 평가

  • Jang, Seon-Il (Division of Beauty Design, School of Human Environment, Wonkwang University) ;
  • Jun, Chang-Soo (Department of Skin & Beauty, Seojeong College) ;
  • Kwak, Kyung-Chell (Department of Skin & Beauty, Seojeong College) ;
  • Bae, Moon-Sung (Department of Skin & Beauty, Seojeong College) ;
  • Lee, Jung-Ho (Department of Skin & Beauty, Seojeong College) ;
  • Kim, Ki-Young (Department of Oriental medical prescription, Wonkwang University) ;
  • Yun, Yong-Gab (Department of Bionanochemistry, College of Natural Science, Wonkwang University) ;
  • Chai, Gyu-Yun (Department of Skin & Beauty, Seojeong College)
  • 장선일 (원광대학교 생활과학대학 미용디자인학부) ;
  • 전창수 (서정대학 피부미용과) ;
  • 곽경철 (서정대학 피부미용과) ;
  • 배문성 (서정대학 피부미용과) ;
  • 이정호 (서정대학 피부미용과) ;
  • 김기영 (원광대학교 한의과대학 방제학교실) ;
  • 윤용갑 (원광대학교 자연과학대학 생명나노화학과) ;
  • 채규윤 (서정대학 피부미용과)
  • Published : 2006.04.25
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Abstract

The inhibitors of prostaglandin $E_2\;(PGE_2)$ production and cyclooxygenase-2 (COX-2) activity have been considered as potential anti-inflammatory agents. In this study, we evaluated 9 compounds isolated from 5 Korean phytomedicinal plants (Spirea prunifolia, Paeonia suffruticosa, Salvia miltiorrhiza, Scutellaria baicalensis, and Artemisia capillaris) for the inhibition of $PGE_2$production and COX-2 expession in lipopolysaccharide (LPS)-stimulated human macrophages U937 cells. As a result, several compound such as prunioside A, penta-O-galloyl-beta-D-glucose, tanshinone IIA, baicalin, baicalein, wogonin, scopolatin, scoparone and decursinol showed potent inhibition of $PGE_2$production (50-70% inhibition at the test concentration of $10\;{\mu}M$). In addition, these compounds were also considered as potential inhibitors of COX-2 activity (45-73% inhibition at the test concentration of $10\;{\mu}M$). These active compound mediating COX-2 inhibitory activities are warranted for further elucidation of active principles for development of anti-inflammatory agents and these properties may contribute to the anti-atopic dermatitis activity.

Keywords

References

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