Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Antifungal Activity of (-)-ent-Costunolide on the Dermatophytic Fungus Trichophyton mentagrophytes

  • Kim, Myung-Ju (Department of Skin & Beauty, Kwangju Health Science College) ;
  • Baek, Seung-Hwa (Department of Herbal Resources, Professional Graduate School of Oriental Medicine and Institute of Basic Natural Sciences, Wonkwang University)
  • Published : 2006.04.25
Download PDF
⟨ Previous Next ⟩

Abstract

Bioactivity directed isolation has led to the isolation of (-)-ent-costunolide (1) as the major active compound. This compound (1) inhibited the growth of the dermatophytic fungus Trichophyton mentagrophytes ATCC 28185, (4 mm inhibition zone at $15\;{\mu}g/disc$).

Keywords

References

  1. Allison, K. W., Child, J. The Liverworts of New Zealand; University of Otago In Press, Dunedin, 1975
  2. Asakawa, Y. In progress in the Chemistry of Organic Natural Products; Herz, W., Kirby, G.W., Moore, R.E., Steglich, W., Tamm, C., Eds.; Springer Vienma, Vol. 65, pp 1-185, 1995
  3. Lorimer, S.D., Barns, G., Evans, A.C., Foster, L.M., May, B. C.H., Perry, N.B., Tangney, R.S. Phytomed. Cytotoxicity and antimicrobial activity of plants from New Zealand's subantarctic islands. 2, 327-333, 1996
  4. Asakawa, Y., Matsuda, R., Cheminat, A. Bibenzyl derivatives form Frullania species. Phytochemistry, 26, 1117-1122, 1987 https://doi.org/10.1016/S0031-9422(00)82361-4
  5. Asakawa, Y., Muller, J.C., Ourisson, G., Foussereau, J., Ducombs, G. New sesquiterpene lactones of Frullania (Hepaticae). Isolation, structures, allergenic properties. Bull. Soc. Chim. Fr. (Chim. Mol.), pp 1465-1466, 1976
  6. Asakawa, Y., Lin, X., Kondo, K., Fukuyama, Y. Chemosy- stematics of bryophytes. Part 47. Terpenoids and aromatic compounds from selected east Malaysian liverworts. Phytochemistry, 30, 4019-4024, 1991 https://doi.org/10.1016/0031-9422(91)83456-U
  7. Kraut, L., Mues, R., Sim-Sim, M. Sesquiterpene lactones and 3-benzylphthalides from Frullania muscicola. Phytochemistry, 37, 1337-1346, 1994 https://doi.org/10.1016/S0031-9422(00)90409-6
  8. Kim, Y.C., Bolzani, V.D.S., Baj, N., Gunatilaka, A.A.L., Kingston, D.G.I. A DNA-damaging sesquiterpene and other constituents from Frullania nisquallensis. Planta Med. 62, 61-63, 1996 https://doi.org/10.1055/s-2006-957800
  9. Baek, S.H., Perry, N.B., Weavers, R.T., Tangney, R.S. Geranyl phenyl ethers from the New Zealand liverwort Trichocolea hatcheri. J. Nat. Prod. 61, 126-129, 1998 https://doi.org/10.1021/np970379b
  10. EI-Feraly, F.S., Chan, Y.M., Capiton, G.A., Doskotch, R.W., Fairchild, E.H. Isolation and characterization of peroxycostunolide (verlotorin) and peroxyparthenolide from Magnolia grandiflora. Carbon-13 nuclear magnetic resonance spectroscopy of costunolide and related compounds. J. Org. Chem. 44, 3952-3955, 1979 https://doi.org/10.1021/jo01336a041
  11. Park, H.J., Jung, W.T., Basnet, P., Kadota, S., Namba, T. Syringin $4-O-{\beta}-glucoside$,a new phenylpropanoid glycoside, and costunolide, a nitrite oxide synthase inhibitor, from the stem bark of Magnolia sieboldii. J. Nat. Prod. 59, 1128-1130, 1996 https://doi.org/10.1021/np960452i
  12. Greene, A.E., Muller, J.C., Ourisson, G. Conversions of alpha-methyl to alpha-methylene-gamma-lactones. Synthesis of two allergenic sesquiterpene lactones. (-)-Frullanolide and (+)-arbusculine B. J. Org. Chem. 39, 186-191, 1974 https://doi.org/10.1021/jo00916a014
  13. Cane, D.E. In Isoprenoids incluing Carotenoids and Steroids; Cane, D.E., ed., Elsevier, Amsterdam, pp 155-200, 1999
  14. Baek, S.H., Lim, J.A., Kwag, J.S., Lee, H.O., Chun, H.J., Lee, J.H., Perry, N.B. Screening for biological activity of crude extract and fractions from Brachyglottis monroi. Kor. J. Orien. Physiol. & Pathol. 17(3):826-828, 2003