Effects of the Combined-administration of Acanthopanacis Cortex and Lycii Cortex Radicis on Immune Response

오가피(五加皮)${\breve{z}}$ -지골피(地骨皮) 병용투여가 면역반응에 미치는 영향

  • Lee, Kyung-A (College of Pharmacy, Woosuk University) ;
  • Park, Hoon (College of Pharmacy, Woosuk University) ;
  • Kwon, Jin (Korea National College of Rehabilitation & Welfare) ;
  • Eun, Jae-Soon (College of Pharmacy, Woosuk University)
  • 이경아 (우석대학교 약학대학) ;
  • 박훈 (우석대학교 약학대학) ;
  • 권진 (한국재활복지대학) ;
  • 은재순 (우석대학교 약학대학)
  • Published : 2006.06.25

Abstract

Immunological activities of the combined-administration of Acanthopanacis Cortex and Lycii Cortex Radicis were examined in BALB/C mice. The 40% ethyl alcohol extract of Acanthopanacis Corter (AE) or the 40% ethyl alcohol extract of Acanthopanacis Coriex and Lycii Cortex Radicis (ALE) were administered p.o. once a day for 7 days, respectively. AE did not affect the viability of thymocytes, but ALE decreased the viability of thymocytes. ALE enhanced the viability of splenocytes increased by AE. Also, AE enhanced the population of cytotoxic T cell in thymocytes, and ALE enhanced the population of helper T cell compared with AE. Furthermore, AE increased the population of $Thy1^+$ cells in splenocytes, and increased the population of splenic $CD4^+$ cells. In addition, ALE enhanced the phagocytic activity which was decreased by AE ALE decreased the production of nitric oxide increased by AE in peritoneal macrophages. These results suggest that ALE enhance an immune-regulative action of AE.

Keywords

References

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