The Korean Journal of Physiology and Pharmacology

The Korean Society of Pharmacology (대한약리학회)
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Changes of Hemodynamics and Renal Function due to Acute Cadmium Exposure in Rats

  • Kim, Jae-Joong (Department of Physiology, College of Medicine, Dongguk University) ;
  • Kim, Yung-Kyu (Department of Physiology, College of Medicine, Dongguk University)
  • Published : 2006.06.21
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Abstract

The systolic and diastolic pressures in anesthetized Sprague-Dawley male rats were greatly decreased after single-dose of Cd treatment without significant changes in heart rate. There was a fluid-shift into the third space and/or -loss through the kidney, since plasma $Na^+$ concentration and hematocrit ratio were significantly increased by acute Cd exposure. The present study showed that the sustained hypotensive effect of single-dose Cd on the cardiovascular system might have resulted from the systemic hypovolemia. Furthermore, renal excretion of electrolytes, including $Na^+$ and $K^+$, and urine flow rate were increased by Cd intoxication. Interestingly, the ratio of $Na^+/K^+$ excretion was increased and reached the maximum level 3 hours after Cd injection and returned to the normal level after 7 hours. Nevertheless, there was no difference in the regression analysis of $Na^+$ excretion and urine flow rate in both groups. Therefore, the increase in the urine volume seemed to enhance the excretion of $Na^+$. This study strongly suggest that the hypotensive effect of Cd is mediated by systemic $Na^+$ loss through the kidney and/or hypovolemia via fluid-shift.

Keywords

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