Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
권호 표지
DOI QR코드

DOI QR Code

Central nervous system stimulating activity of the ethanolic extract of Fleurya interrupta Guad. (Urticaceae)

  • Shilpi, Jamil Ahmad (Phytochemical and Pharmacological Research Laboratory, Pharmacy Discipline, Life Science School, Khulna University) ;
  • Rouf, Razina (Phytochemical and Pharmacological Research Laboratory, Pharmacy Discipline, Life Science School, Khulna University) ;
  • Ferdous, MM (Department of Botany, University of Rajshahi) ;
  • Uddin, Shaikh Jamal (Phytochemical and Pharmacological Research Laboratory, Pharmacy Discipline, Life Science School, Khulna University)
  • Published : 2006.03.30
Download PDF
⟨ Previous Next ⟩

Abstract

The ethanolic extract of Fleurya interrupta Gaud, (Urticaceae) was tested for its possible neuropharmacological effects on experimental animals, For the primary neuropharmacological screening of this plant, the ethanolic extract of its aerial parts was subjected to preliminary evaluation for acute toxicity, antinociceptive activity and central nervous system (CNS) activities. At the doses of 125 and 250 mg/kg, the extract significantly (P < 0.01 and P < 0. 001) and dose-dependently increased the frequency of acetic acid induced writhing in mice. In the pentobarbitone induced sleeping time test, the extract at the above dose levels, significantly and dose-dependently decreased the pentobarbitone induced sleeping time (P < 0.001) and increased the time for onset of sleep (P < 0.001) in mice. In the open field and hole cross tests, test animals showed an increase in their movement in the both tests from the 2nd observation period (30 min) and persisted throughout the entire experimental period (240 min). These results of the extract may attribute a stimulating action on the CNS. On the basis of these findings, it can be assumed that the extract exerts its stimulating effect on the CNS in mice by interfering with the cortical function or increasing the effect of some CNS stimulating neurotransmitters.

Keywords

References

  1. Collier HO, Dinneen LC, Johnson CA, Schneider C. (1968) The abdominal constriction response and its suppression by analgesic drags in the mouse. Br. J. Pharmacol. 32, 295-310.
  2. Dinda D, Chel G, Das A. (1988) Studied on the relative percentage abundances of the components fatty acids of Fleurya interrupta. J. Indian Chem. Soci. 65, 227-228.
  3. Dinda D, Chel G, Das A, Poria M, Debnath S. (1990) Studied on the relative percentage abundances of the components fatty acids of Fleurya interrupta. J. Indian Chem. Soci. 67, 528.
  4. Goodman, Gilman. (2001) The Pharmacological Basis of Therapeutics, edited by Hardman JG, Limbird LE, p. 413, 10th Ed. McGraw-Hill, USA.
  5. Guaraldo L, Chagas DA, Konno AC, Korn GP, Pfiffer T, Nasello AG. (2000) Hydroa1coholic extract and fractions of Davilla rugosa Poiret: effects on spontaneous motor activity and elevated plus-maze behavior. J. Ethnopharmacol. 72, 61-67. https://doi.org/10.1016/S0378-8741(00)00198-7
  6. Gupta BD, Dandiya PC, Gupta ML. (1971) A psychopharmacological analysis of behavior in rat. Jpn. J. Pharmacol. 21, 293. https://doi.org/10.1254/jjp.21.293
  7. Harborne JB. (1984) Phytochemal methods (A guide to modern techniques to plant analysis). 3rd ed. Chapman and Hall, London.
  8. Islam MS, Rahman MT, Rouf ASS, Rahman F. (2003) Evaluation of neuropharmacological effects of Rumex maritimus Linn. (Polygonaceae) root extracts. Pharmazie 58, 738-741.
  9. Ikeda Y, Ueno A, Naraba H, Oh-ishi S. (2001) Involvement of vanilloid receptor VRl and prostanoids in the acid-induced writhing responses of mice. Life Sci. 69, 2911-2919. https://doi.org/10.1016/S0024-3205(01)01374-1
  10. Koster R, Anderson M, Beer EJ. (1959) Acetic acid for analgesic screening. Fed. Proc. 18, 412-415.
  11. Lorke D. (1983) A new approach to acute toxicity testing. Arch. Toxicol. 54, 275-287. https://doi.org/10.1007/BF01234480
  12. Murata T, Ushikubi F, Matsuoka T, Hirata M, Yamasaki A, Sugimoto Y, Ichikawa A. ze Y, Tanaka T, Yoshida N, Ueno A, Oh-Ishi S, Narumiya S. (1997) Altered pain perception and inflammatory response in mice lacking prostacyclin receptor. Nature 388, 678-682. https://doi.org/10.1038/41780
  13. Prain D. (1981) Bengal plants, pp. 960-961. Bishen Singh Mahendra Pal Singh Publisher, Dehradun, India.
  14. Raj PP. (1996) Pain mechanisms. In: Pain Medicine, pp. 12-24, A Comprehensive Review, first ed. Mosby-Year Book, Inc., St. Louis, USA.
  15. Shilpi JA, Uddin SJ, Rouf R, Billah MM. (2004) Central nervous system depressant activity of Diospyros peregrina bark. Orient. Pharm. Exp. Med. 4, 249-252. https://doi.org/10.3742/OPEM.2004.4.4.249
  16. Shilpi JA, Ray PK, Uddin SJ. (2005) Analgesic activity of Amorphophallus campanulatus tuber. Fitoterapia (in press).
  17. Smith AC. (1981) Flora Vitiensis nova: A new flora of Fiji, Lawai, Kauai, Hawaii. National Topical Botanical Gaeden 2, 215-216.
  18. Takagi K, Watanabe M, Saito H. (1971) Studies on the spontaneous movement of animals by the hole cross test: Effect of 2-dimethylaminoethane. Its acylates on the central nervous system. Jpn. J. Pharmacol. 21, 797. https://doi.org/10.1254/jjp.21.797
  19. Uddin SJ, Shilpi JA, Alam SMS, Alamgir M, Rahman MT, Sarker SD. (2005) Antidiarrhoeal activity of the methanol extract of the barks of Xylocarpus molucensis in castor oil and magnesium sulphate-induced diarrhoea models in mice. J. Ethnopharmacol. 101, 139-143. https://doi.org/10.1016/j.jep.2005.04.006
  20. Uddin SJ, Shilpi JA. Barua J, Rouf R. (2005) Antinociceptive activity of Ceriops decandra leaf and pneumatophore. Fitoterapia 76, 261-263. https://doi.org/10.1016/j.fitote.2004.12.015
  21. Uddin SJ, Shilpi JA. Delazar A. Nahar L, Sarker SD. (2004) Free radical scavengingactivity of some Bangladeshi plant extracts. Orient. Pharm. Exp. Med. 4, 185-193.
  22. Uddin SJ, Shilpi JA, Rahman MT, Ferdous MM, Rouf R, Sarker SD. (2005) Assessment of neuropharmacological activities of Pandanus foetidus (Pandanaceae) in mice. Pharmazie (In press).
  23. Wagner WL, Herbst DR, and Shomer SH. (1999) Manual of flowering plants of Hawaii, p. 1299, Revised edition, University of Hawaii Press, Honolulu.
  24. Williamson EM, Okpako DT, Evans FJ. (1996) Selection, Preparation and Pharmacological Evaluation of Plant Material. In: Pharmacological Methods in Phytotherapy Research, Vol 1, 1st ed, p. 184, John Willey & Sons, England.

Cited by

  1. Analgesic and antioxidant activities of Colocasia fallax vol.16, pp.2, 2016, https://doi.org/10.1007/s13596-016-0222-1