Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects of Fermented Rice Wine Using Mycelium of Phellinus linteus on the Gastric Mucosa of Rat

상황버섯 균사체를 이용한 발효주가 흰쥐의 위점막에 미치는 영향

  • Lee Soo-Jin (Departments of Anatomy, College of Oriental Medicine, Dong-eui University) ;
  • Choi Yung-Hyun (Department of Biochemistry, College of Oriental Medicine, Department of Biomaterial Control, Graduate School, Dong-eui University) ;
  • Lee Yong-Tae (Department of Physiology, College of Oriental Medicine, Dong-eui University) ;
  • Chung Kyung-Tae (Department of Life Science and Biotechnology, College of Natural Science, Dong-eui University) ;
  • Jeong Young-Kee (Department of Life Science and Biotechnology, College of Natural Science, Dong-eui University) ;
  • Choi Byung-Tae (Departments of Anatomy, College of Oriental Medicine, Department of Biomaterial Control, Graduate School, Dong-eui University)
  • 이수진 (동의대학교 한의과대학 해부학교실) ;
  • 최영현 (동의대학교 한의과대학 생화학교실, 대학원 바이오물질제어학과) ;
  • 이용태 (동의대학교 한의과대학 생리학교실) ;
  • 정경태 (동의대학교 자연과학대학 생명응용과학과) ;
  • 정영기 (동의대학교 자연과학대학 생명응용과학과) ;
  • 최병태 (동의대학교 한의과대학 해부학교실, 대학원 바이오물질제어학과)
  • Published : 2006.02.01
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Abstract

It was examined the effect of fermented rice wine using mycelium of Phellinus linteus (FWPL) on the gastric mucosa of rat. The gastric mucosal lesions were not seen macroscopically in normal, but ethanol-administrated rats produced congestion and edema with a few local lesions. The administration of FWPL showed a similar pattern as like normal except trace histopathological changes. The results of Western blot analyses showed that the higher expression of inducible nitric oxygenase (iNOS), cyclooxygenase (COX)-1, COX-2, tumor necrosis factor-$\alpha$ and c-fos, especially COX-2, in the ethanol-administrated rat compared with normal rat. But FWPL-administrated rat showed a trace increase of these expression compared to normal rat. About immunohistochemical observations, weaker iNOS reactions were detected in mucous cells of epithelim of ethanol administrated rat compared with normal and FWPL-administrated rat. These results suggested that FWPL-administrated rat showed a trace changes on the mucus barrier-related protein expression compared with ethanol-administrated rat and thus FWPL may be use to develop a functional alcoholic beverage.

Keywords

References

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