Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Inhibitory Effects of the Methanolic Fraction from Pueraria Radix on Hydrogen Peroxide-induced Lipid Peroxidation and Cadmium-induced Cytotoxicity (III)

갈근 메탄올분획의 과산화수소에 의해 유도된 지질과산화와 카드뮴에 대한 독성억제효과 (III)

  • Lim, Jin-A (Department of Cosmetic Science, Wonkwang Health Science) ;
  • Kim, Yun-Ha (Department of Herbal Resources, Professional Graduate School of Oriental Medicine and Institute of Basic Natural Sciences Wonkwang University) ;
  • Baek, Seung-Hwa (Department of Herbal Resources, Professional Graduate School of Oriental Medicine and Institute of Basic Natural Sciences Wonkwang University)
  • 임진아 (원광보건대학 화장품과학과) ;
  • 김연하 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 백승화 (원광대학교 한의학전문대학원 한약자원개발학과)
  • Published : 2006.12.25
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Abstract

The effects of the methanol subfraction from Pueraria Radix on hydrogen peroxide-induced lipid peroxidation and cadmium-induced cytotoxicity were investigated in NIH 3T3 fibroblast cells. After the methanol subfraction treatment, the content of MDA induced by 600 ${\mu}g$ $H_2O_2$ significantly decreased in proportion to the subfraction concentrations as well as 50 ${\mu}M$ $CdCl_2$-induced cytotoxicity. Especially, 200 ${\mu}g/mL$ concentration of methanol subfraction was strongly shown inhibition of lipid peroxidation and detoxification of cadmium. These results suggest that the methanol subfraction from Pueraria Radix retains a potential antioxidant and protective effect against cadmium.

Keywords

References

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