Effects of Cnidium officinale, Petasites japonicus, Coptis chinensis Extract Mixture on Vasodilation

천궁(川芎), 머위, 황련(黃連) 추출물 조성의 $Ca^{2+}$ 유입 억제를 통한 혈관이완 효능

  • Kim, Sang-Dae (Department of Physiology, college of Oriental Medicine, Dongguk University) ;
  • 김길훤, Gil-Whon (Department of Physiology, college of Oriental Medicine, Dongguk University) ;
  • Shin, Heung-Mook (Department of Physiology, college of Oriental Medicine, Dongguk University)
  • 김상대 (동국대학교 한의과대학 생리학교실) ;
  • 김길훤 (동국대학교 한의과대학 생리학교실) ;
  • 신흥묵 (동국대학교 한의과대학 생리학교실)
  • Published : 2006.12.25

Abstract

This study was performed to investigate a vasodilatory efficacy and its underlying mechanisms of the mixture of Cnidium officinale, Petasites japonicus and Coptis chinensis (CPC), CPC relaxed rat aortic vascular strips in endothelium-independant manner precontracted with phenylephrine or KCI(50mM), but the magnitude of relaxation was greater in KCI induced contraction. L-NAME, iNOS inhibitor, and methylen blue(MB), cGMP inhibitor, did not attenuate the relaxation responses of CPC. Furthermore, the contraction by increaseing $Ca^{2+}$ concentration (0.3-10.0mM) to a $Ca^{2+}$-free high $K^+$ (60mM) was significantly reduced by CPC pretreatment. These results suggest that the relaxation effect of CPC is related with the block of $Ca^{2+}$ influx via $Ca^{2+}$ channel.

Keywords

References

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