Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Inhibitory Effect of Hwalhyul Composition on Inflammatory Responses in Rheumatoid Arthritis

  • Lim, Chang-Bum (Department of Oriental medicine, College of Oriental Rehabilitation Medicine, Daejeon University) ;
  • Yoon, Il-Ji (Department of Oriental medicine, College of Oriental Rehabilitation Medicine, Daejeon University) ;
  • Oh, Min-Suck (Department of Oriental medicine, College of Oriental Rehabilitation Medicine, Daejeon University)
  • Published : 2006.12.25
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Abstract

This study was performed to examine whether HC is effective in controlling molecular components known to be involved in RA, FLS were used to determine possible regulatory effects of HC on levels of inflammatory cytokines. Major findings are summarized as follows. TNF-${\alpha}$ mRNA expression levels in FLS cells which had been repressed by 10, 100 ${\mu}g/m{\ell}$ of HC treatment. IL-6 mRNA expression levels in FLS cells which had been repressed by 10, 100 ${\mu}g/m{\ell}$ of HC treatment. IL-1${\beta}$ mRNA expression levels in FLS cells which had been repressed by 10, 100 ${\mu}g/m{\ell}$ of HC treatment. The present data suggest that FLS which has been activated by IL-1 and TNF-${\alpha}$ co-treatment decreased production of inflammatory cytokines then, HC treatment by repressed the production of these molecules.

Keywords

References

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