Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Modulation of Sarcodon Aspratus on lon Currents-induced by Excitatory Neurotransmitters in Rat Periaqueductal Gray Neurons

  • Kim, Sung-Tae (Department of Anatomy-Pointology, College of Oriental Medicine, Kyungwon University) ;
  • Sung, Yun-Hee (Department to Physiology, College of Medicine, Kyung Hee University) ;
  • Kim, Chang-Ju (Department to Physiology, College of Medicine, Kyung Hee University) ;
  • Joo, Kwan-Joong (Department of Urology, College of Medicine, Sungkyunkwan Univeristy) ;
  • Han, Seung-Ho (Department of Physiology, College of Medicine, Eulji University) ;
  • Lee, Choong-Yeol (Department of Physiology, College of Oriental Medicine, Kyungwon University) ;
  • Kim, Youn-Sub (Department of Anatomy-Pointology, College of Oriental Medicine, Kyungwon University)
  • Published : 2006.12.25
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Abstract

Sarcodon aspratus is the mushroom of Telephoracea which was been classified into Alphllophorales. The aqueous extract of Sarcodon aspratus in known to have anti-tumor activity, immune modulatory effect, and anti-oxidative action. The descending pain control system consists of three major components: the periaqueductal gray (PAG) of the midbrain, the rostroventral medulla including the nucleus raphe magnus, and the spinal dorsal horn. Glutamate is the primary excitatory neurotransmitter in the brain. Glutamate ionotropic receptors are classified as N-methyl-D-aspartate (NMDA) receptor, ${\alpha}$-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor, and kainate receptor. In the present study, the modulation of Sarcodon aspratus on the ion currents activated by glutamate, NMDA, AMPA, and kainate in the acutely dissociated PAG neurons was investigated by nystatin-perforated patch-clamp technique under boltage-clamp condition. Sarcodon aspratus increased glutamate- and NMDA-induced ion currents were not increased by Sarcodon aspratus. The present results show that Sarcodon aspratus may activate the descending pain control system in rat PAG neurons through NMDA receptor.

Keywords

References

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