Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Cytotoxicity of Angelicae Radix from Korea, China, and Japan on HepG2 Cells

한국 ${\cdot}$ 중국 ${\cdot}$ 일본 당귀(當歸)의 HepG2 세포 독성 비교 연구

  • Park, Wan-Su (Department of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • Oh, Myung-Sook (Department of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • Chang, Mun-Seog (Department of Medicine, Division of Newborn Medicine, Children's Hospital and Harvard Medical School) ;
  • Yang, Woong-Mo (Department of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • Lee, Byong-Hee (Department of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Won-Nam (Department of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • Lee, Hak-Chul (Department of Oriental Preventive Medicine, College of Oriental Medicine, Dong-Eui University) ;
  • Kang, Soon-Ah (Department of Fermented Food Science, Seoul University of Venture & Information) ;
  • Park, Seong-Kyu (Department of Prescriptionology, College of Oriental Medicine, Kyung Hee University)
  • 박완수 (경희대학교 한의과대학 처방제형학교실) ;
  • 오명숙 (경희대학교 한의과대학 처방제형학교실) ;
  • 장문석 (하버드대학교 의과대학 소아병원) ;
  • 양웅모 (경희대학교 한의과대학 처방제형학교실) ;
  • 이병희 (경희대학교 한의과대학 처방제형학교실) ;
  • 김원남 (경희대학교 한의과대학 처방제형학교실) ;
  • 이학철 (동의대학교 한의과대학 예방의학교실) ;
  • 강순아 (서울벤처정보대학원대학교 발효식품과학과) ;
  • 박성규 (경희대학교 한의과대학 처방제형학교실)
  • Published : 2006.10.25
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Abstract

The purpose of this study is to examine the cytotoxicity of species of Angelica (Angelicas Radix; the root of Angelica gigas Nakai, A. sinensis (Oliv.) Diels, and A. acutiloba Kitag.) on HepG2 cells. The water extracts of roots of Angelica gigas (WAG), A. sinensis (WAS), and A. acutiloba (WAA) were studied for HepG2 cell viability by a modified MTT assay in the concentrations of 5, 10, 50, 100, 250, 500 ug/ml for 24, 48, 72 h. WAG and WAS did not reduced the cell viability significantly. But WAA reduced the cell viability in the concentration of 500 ug/ml for 24 h (85.45%), 48 h (75.01%). In conclusion, WAG and WAS have not the significant cytotoxicity on HepG2 cells in the suitable dose.

Keywords

References

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