Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Study on the Mechanism of Vascular Relaxation Induced by Cortex Caryphylli

정향피 추출물의 혈관 이완효과 및 작용기전에 대한 연구

  • Song, Chul-Min (College of Oriental Medicine, Wonkwang University) ;
  • Shin, Sun-Ho (College of Oriental Medicine, Wonkwang University) ;
  • Jung, Hyun-Ae (College of Oriental Medicine, Wonkwang University) ;
  • Lee, Jun-Kyoung (Professional Graduate School of Orienal Medicine, Wonkwang University) ;
  • Cao, Li-Hua (Professional Graduate School of Orienal Medicine, Wonkwang University) ;
  • Kang, Dae-Gil (Professional Graduate School of Orienal Medicine, Wonkwang University) ;
  • Lee, Ho-Sup (Professional Graduate School of Orienal Medicine, Wonkwang University)
  • Published : 2006.10.25
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Abstract

The aqueous extracts of Cortex Caryophylli (AEC) induced dose-dependent relaxation of phenylephrine-precontracted aorta, which was abolished by removal of functional endothelium. Pretreatment of the endothelium-intact aortic tissues with N$^G$_nitro-L-arginine methyl ester (L-NAME) or 1 H-[1,2,4]-oxadiazole-[4,3-${\alpha}$l-quinoxalin-1-one (ODQ) inhibited the relaxation induced by AEC. AEC-induced vascular relaxations were also markedly attenuated by addition of verapamil, diltiazem and glibenclamide, tetraethylammonium (TEA), respectively, while the relaxation effect of AEC was not blocked by indomethacin, atropine, or propranolol. Moreover, incubation of endothelium-intact aortic rings with AEC increased the production of cGMP. These results suggest that AEC dilates vascular smooth muscle via endothelium-dependent nitric oxide/cGMP signaling, which seems to be causally related with L-type Ca$^{2+}$ and K$^+$ channels.

Keywords

References

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